Amrothman

Amr Othman Abdekareem Mohammad Ahmad

Lecturer - Lecturer

Faculty of medicine

Address: Obstetrics and Gynecology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.

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Experienced Lecturer of Obstetrics and Gynecology with a demonstrated history of working in the Medical education and Medical Research . Consultant of Obstetrics and Gynecology with focus on Reproductive endocrinology and infertility, Minimally invasive Gynecological surgery and Emergency Obstetrics and Gynecology health care. Strong education professional with a Bachelor of Medicine and Surgery (Excellent degree with Honors), Masters and Doctorate degree in Obstetrics and Gynecology.

Immunoreactivity of Kisspeptin and Kisspeptin Receptor in Eutopic and Ectopic Endometrial Tissue of Women With and Without Endometriosis

2020-03-03 08:23:59 | Keywords metastin, KISS1, Endometriosis, Kisspeptin, Immunohistochemistry,
Immunoreactivity of Kisspeptin and Kisspeptin Receptor in Eutopic and Ectopic Endometrial Tissue of Women With and Without Endometriosis
Endometriosis is characterized by the presence of ectopic endometrial tissues. Mechanisms of tissue dissemination in endometriosis may be similar to those involved in tumor metastasis. We hypothesize that dysregulation of kisspeptin (KISS1), a metastasis suppressor in endometrial carcinoma, may contribute to the pathogenesis of endometriosis. In this study, we characterized the immunoreactivity of kisspeptin and its receptor, KISS1R, in eutopic ... Read more

Plasminogen activator inhibitor-1 (PAI-1) expression in endometriosis

2020-01-16 03:52:03 | Keywords PAI-1, IHC, Endometriosis,
Plasminogen activator inhibitor-1 (PAI-1) expression in endometriosis
ABSTRACT PURPOSE Deep infiltrating endometriosis (DIE) is defined as an endometriotic lesion penetrating to a depth of >5 mm and is associated with pelvic pain, but the underlying mechanisms are unclear. Our objective is to investigate whether plasminogen activator inhibitor-1 expression (PAI-1) in endometriotic tissues is increased in women with DIE. METHODS In this blinded _in vitro_ study, immunohistochemistry and ... Read more

Prevalence of thyroid autoimmunity and effect of levothyroxine treatment in a cohort of 1064 patients with recurrent pregnancy loss

2020-01-16 03:58:18 | Keywords RPL, Hypothyroidism, TSH,
Prevalence of thyroid autoimmunity and effect of levothyroxine treatment in a cohort of 1064 patients with recurrent pregnancy loss
ABSTRACT RESEARCH QUESTION Does initiating levothyroxine treatment based on Thyroid Stimulating Hormone (TSH) > 2.5 mIU/L or thyroid autoimmunity improve pregnancy continuation rates in recurrent pregnancy loss (RPL) patients? DESIGN We conducted a retrospective cohort study of 1064 RPL patients. Subjects were classified as either euthyroid (TSH 0.1 - ≤ 2.5 mIU/L), borderline-subclinical hypothyroid (borderline-SCH, TSH 2.5 – ≤ 4 ... Read more

Endometrial leukemia inhibiting factor (LIF) and integrin αvβ3 (ITG αvβ3) expression after kisspeptin trigger of ovulation in mice

2018-09-19 05:58:08 | Keywords kisspeptin implantation IVF,
Endometrial leukemia inhibiting factor (LIF) and integrin αvβ3 (ITG αvβ3) expression after kisspeptin trigger of ovulation in mice
OBJECTIVE: Kisspeptin (KISS-1) is a hypothalamic neuropeptide that regulates hypothalamic pituitary ovarian axis function. Pre-ovulatory rise in serum KISS-1 leads to luteinizing hormone (LH) surge that triggers final oocytes maturation and ovulation. Exogenous trigger of ovulation is used in ovarian hyper-stimulation for some infertility cases. KISS-1 and its receptor (KISS-1R) are also expressed in the endometrium. Previous studies in mice ... Read more

Clinical, Hormonal, and Metabolic Parameters in Women with Subclinical Hypothyroidism and Polycystic Ovary Syndrome: A Cross-Sectional Study

2018-09-13 04:08:05 | Keywords Subclinical Hypothyroidism, Insulin Resistance, Impaired fasting glucose, Polycystic ovary syndrome,
Clinical, Hormonal, and Metabolic Parameters in Women with Subclinical Hypothyroidism and Polycystic Ovary Syndrome: A Cross-Sectional Study
_BACKGROUND:_ Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in reproductive age women, yet its clinical presentation shares similarities with several other endocrine disorders such as thyroid disease. Hence, the objective of this study was to further evaluate this association by investigating the clinical, hormonal, and metabolic parameters between subclinical hypothyroidism (SCH) and PCOS. _METHODS:_ This is a cross-sectional ... Read more

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