amr_hassanegypt

Amr Hassan Moustafa Ahmed

Assistant Professor - Assistant Professor

Faculty of science

Address: Al-Iman Tower, Al-Sharaieh Street, behind the university's dormitory for girls' students, Nasser City - Sohag

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Dr Amr H. Moustafa received the Chemistry doctoral degree (PhD) in Synthetic Organic Chemistry from Faculty of Chemistry, Voronezh State University, Voronezh-Russia in 2013. Currently, he is an Associate Professor of Organic Chemistry at Sohag University, Egypt. His research interests are geared towards synthesis of new organic compounds with their high expected biological activities. These syntheses are considered by multi-component reactions, new green solvents and using new conditions in organic syntheses. Physical characterization of new synthetic organic compounds using high technique FTIR, 1H, 13C, Dept-135, Dept-90 NMR, elemental analysis and X-ray crystallographic. The mechanism of reactions is assumed.

3. Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies

2019-12-10 00:08:59 | Keywords Aryl carboximidamides 1, 4-, Aryl carboximidamides, 4-oxadiazoles, COX-1, 15- LOX, Naproxen, anti-inflammatory, COX-2, 1, 2, 2,
3. Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies
A series of novel naproxen analogues containing 3-aryl-1,2,4-oxadiazoles moiety (4b-g) and their reaction intermediates aryl carboximidamides moiety (3b-g) was synthesized and evaluated in vitro as dual COXs/15-LOX inhibitors. Compounds 3b-g exhibited superior inhibitory activity than celecoxib as COX-2 inhibitors. Compounds 3b-d and 3g were the most potent COX-2 inhibitors with IC50 range of 6.4 – 8.13 nM and higher selectivity ... Read more

2. A regioselective and convenient one-pot multicomponent synthesis of polyfunctionalized 4-aryl-2-cyanoimino-3,4-dihydro-1H-pyrido[2,3-d]pyrimidines

2019-12-10 00:15:17 | Keywords stereoselective, pyrido[2, 3-d]pyrimidine, spiro pyrimidine, multicomponent reactions, MCRs, Cyanoiminopyrimidine, Cyanoguanidine,
2. A regioselective and convenient one-pot multicomponent synthesis of polyfunctionalized 4-aryl-2-cyanoimino-3,4-dihydro-1H-pyrido[2,3-d]pyrimidines
A novel series of 5,7-diamino-4-aryl-6-cyano-2-cyanoimino-3,4-dihydro-1H-pyrido[2,3-d]pyrimidines (aryl-CIDHPPMs) 3a–i was prepared via the one-pot four-component reaction of cyanoguanidine with aromatic aldehydes and malononitrile with molar ratio (1:1:2) using sodium methoxide as catalyst. These new polyfunctionlized aryl-CIDHPPMs were also synthesized by a classical route via reaction of cyanoguanidine with the respective arylidenes of malononitrile dimer under the same condition. In the same manner, ... Read more

An Efficient Synthesis of Benzylidene-2-alkoxy-4-aryl-2,3-cycloalkenopyridine-3-carbonitrile Derivatives

2019-12-10 00:21:16 | Keywords Benzylidene, cyanopyridine, cyclic ketone, 3-cycloalkenopyridine, multi-component reaction, 2,
An Efficient Synthesis of Benzylidene-2-alkoxy-4-aryl-2,3-cycloalkenopyridine-3-carbonitrile Derivatives
An efficient procedure for the synthesis of a novel class of benzylidene-2-alkoxy-4-aryl-6,7-dihydro-5H-cyclopenta[b]pyridine-, -5,6,7,8-tetrahydroquinoline and/or -6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine- 3-carbonitrile was introduced through the one-pot multicomponent reaction of cyclopentanone, cyclohexanone, and/or cycloheptanone with different aromatic aldehydes and malononitrile. The same products were also produced by classical route by the two-component reaction of dibenzylidine cyclopentanone, cyclohexanone, and/or cycloheptanone derivatives with malononitrile. The reactions were achieved ... Read more

New Polymer Syntheses Part 60: A Facile Synthetic Route to Polyamides Based on Thieno[2,3-b]thiophene and Their Corrosion Inhibition Behavior

2018-09-24 12:49:16 | Keywords Thieno[2, 3-b]thiophene,
New Polymer Syntheses Part 60: A Facile Synthetic Route to Polyamides Based on Thieno[2,3-b]thiophene and Their Corrosion Inhibition Behavior
Polyamides containing thieno[2,3-_b_]thiophene moiety were prepared _via_ a simple polycondensation reaction of the diaminothieno[2,3-_b_]thiophene monomer 1A with different kinds of diacid chlorides (including oxalyl, adipoyl, sebacoyl, isophthaloyl, terephthaloyl, 4,4′-azodibenzoyl, 3,3′-azodibenzoyl, _p_-phenylene diacryloyl) in the presence of LiCl and NMP as a solvent through low-temperature solution polycondensation. The chemical structures of model compound and synthesized polyamides were confirmed by FTIR, nuclear ... Read more

Unexpected products from the reaction of chalcones with cyanoguanidine

2018-09-24 12:25:13 | Keywords Dihydrochalcones (DHCs),
Unexpected products from the reaction of chalcones with cyanoguanidine
A new series of unexpected dihydrochalcones DHCs attached with cyanoiminopyrimidine moiety in addition to expected cyanoaminopyrimidines CAMPs were synthesized by efficient and facile method via reaction of cyanoguanidine with chalcone derivatives in the presence of EtONa. Read more

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