Dr. Mamdouh Fawzy Ahmed Mohamed

Lecturer of pharmaceutical Chemistry

Sohag University

Faculty of Pharmacy

Pharmaceutical Chemistry Department

Phone: 01018384461

mamdouh.fawzi@pharm.sohag.edu.eg

Medicinal chemistry and molecular pharmacology of Histone Deacetylase Inhibitors; drug development; inflammatory and neurodegenerative diseases; cancer. Key questions: which is more effective, pan-HDACis or isoform selective HDACis? Can we develop potent and selective drugs addressing those targets? Do these drugs show effects in other disease models?

Techniques

Molecular biology, in vitro pharmacology, compound screenning, assay development, chemical synthesis, analytical techniques, analysis of structure-activity relationships.

3 most important publications

1. Mamdouh F. A. Mohamed, Montaser Sh. A. Shaykoon, Mostafa H. Abdelrahman, Bakheet E. M. Elsadek, Ahmed S. Aboraia, Gamal El-Din A. A. Abuo-Rahma, Design, synthesis, docking studies and biological evaluation of novel chalcone derivatives as potential histone deacetylase inhibitors, Bioorg. Chem., 72, (2017), 32–41.
2. Youssif, B. G. M.; Abdelrahman, M. H.; Abdelazeem, A. H.; Abdelgawad, M. A.; Ibrahim, H. M.; Salem, O. I. A.; Mohamed, M. F. A.; Treambleau, L.; Bukhari, S. N. A., Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production. Eur. J. Med. Chem. 2018, 146, 260-273.
3. Abdelbaset, M. S.; Abuo-Rahma, G. E. A.; Abdelrahman, M. H.; Ramadan, M.; Youssif, B. G. M.; Bukhari, S. N. A.; Mohamed, M. F. A.; Abdel-Aziz, M., Novel pyrrol-2(3H)-ones and pyridazin-3(2H)-ones carrying quinoline scaffold as anti-proliferative tubulin polymerization inhibitors. Bioorg. Chem. 2018, 80, 151-163.

• Announcements
• Publications
• Courses Tasks

لوجو قسم الكيمياء الصيدلية - كلية الصيدلة - جامعة سوهاج

2018-10-29 08:19:26

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Design, synthesis and anticancer activity of novel valproic acid conjugates with improved histone deacetylase (HDAC) inhibitory activity

2020-04-08 05:07:14 | Keywords Valproic acid; Anticancer;,

Twenty-five valproic acid conjugates have been designed and synthesized. All target compounds were explored for their in vitro anti-proliferative activities using the MTT-based assay against four human cancer cell lines includingliver (HePG2), colon (HCT116), breast (MCF7) and cervical (HeLa) carcinoma cell lines. Out of six valproic acid-amino acid conjugates 2a-f. Only cysteine containing conjugate 2f showed the significant activity (IC50 ... Read more

Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety

2020-02-04 19:06:32 | Keywords In silico study, Anticancer agents, Ligustrazine, HDACs Inhibitors;, Synthesis, , , ,

INTRODUCTION: Histone deacetylases (HDACs) represent one of the most validated cancer targets. The inhibition of HDACs has been proven to be a successful strategy for the development of novel anticancer candidates. METHODS: This work describes design and synthesis of a new set of HDAC inhibitors ( 7A-C and 8A, B) utilizing ligustrazine as a novel cap moiety, and achieving the ... Read more

Optimization of the synthesis of het/aryl-amidoximes using an efficient green chemistry

2020-03-15 21:15:14 | Keywords 4-oxadiazole, optimization;, cyanamide;, arylnitrile;, arylamide;, Amidoxime;, pyrimidine;, 2, 1,

This work focuses on optimizing an efficient green synthesis of arylamidoximes from appropriate nitrile and hydroxylamine hydrochloride in water and triethylamine (1.6 mol equivalent) as a base at room temperature for 6 h. This new green synthetic methodology is compared with previously known methods. The main advantages of this new process reported are good yield, easier work-up and short reaction ... Read more

Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies

2019-04-26 22:38:01 | Keywords COX-1, 4-oxadiazoles, Aryl carboximidamides, 4-o, Aryl carboximidamides1, Naproxe, 15- LOX, anti-inflammatory, COX-2, 1, 2, 2,

A series of novel naproxen analogues containing 3-aryl-1,2,4-oxadiazoles moiety (4B-G) and their reaction intermediates aryl carboximidamides moiety (3B-G) was synthesized and evaluated _in vitro_ as dual COXs/15-LOX inhibitors. Compounds 3B-G exhibited superior inhibitory activity than celecoxib as COX-2 inhibitors. Compounds 3B-D and 3G were the most potent COX-2 inhibitors with IC50 range of 6.4 – 8.13 nM and higher selectivity ... Read more

EGFR inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and docking studies of novel xanthine derivatives carrying chalcone moiety as hybrid molecules

2019-05-25 20:49:41 | Keywords Apoptotic assay., EGFRAnti-proliferative;, Hybrids;, Chalcone;, Xanthine;,

One of the helpful ways to improve the effectiveness of anticancer agents and weaken drug resistance is to use hybrid molecules. therefore, the current study intended to introduce 20 novel xanthine/chalcone hybrids 9-28 of promising anticancer activity. Compounds 10, 11, 13, 14, 16, 20 and 23exhibited potent inhibition of cancer cells growth with IC50 ranging from 1.0±0.1 to 3.5±0.4 μM ... Read more

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Task 1

2018-10-29 07:52:09 | Pharmaceutical Organic Chemistry-3

* Arrange the reactivity of the following compounds toward electrophilic aromatic substitution, give reasons? * Read more

task 2

2018-10-29 05:36:43 | Pharmaceutical Organic Chemistry-I

2- Give both the IUPAC and common nomenclature of the following compounds and indicate the type of each alkyl halide? Read more

task 1

2018-09-09 09:03:10 | Pharmaceutical Organic Chemistry-I

* 1- Arrange the reactivity of the following alkyl halide towards SN2 reaction, justify your answer? * Ethyl iodide * Butyl iodide * Methyl iodide * iso-Propyl iodide Read more

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