mamdouh.fawzi

Mamdouh Fawzy Ahmed Mohamed

Lecturer - Lecturer and Co-ordinate of Pharmaceutical Chemistry and Co-ordinate of Clinical Pharmacy Program

Faculty of Pharmacy

Address: جمهورية مصر العربية - سوهاج - مركز البلينا - الحلافى الغربية

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Dr. Mamdouh Fawzy Ahmed Mohamed

Lecturer of pharmaceutical Chemistry

Sohag University

Faculty of Pharmacy

Pharmaceutical Chemistry Department

Phone: 01018384461

mamdouh.fawzi@pharm.sohag.edu.eg

Medicinal chemistry and molecular pharmacology of Histone Deacetylase Inhibitors; drug development; inflammatory and neurodegenerative diseases; cancer. Key questions: which is more effective, pan-HDACis or isoform selective HDACis? Can we develop potent and selective drugs addressing those targets? Do these drugs show effects in other disease models?

Techniques

Molecular biology, in vitro pharmacology, compound screenning, assay development, chemical synthesis, analytical techniques, analysis of structure-activity relationships.

3 most important publications

  1. Mamdouh F. A. Mohamed, Montaser Sh. A. Shaykoon, Mostafa H. Abdelrahman, Bakheet E. M. Elsadek, Ahmed S. Aboraia, Gamal El-Din A. A. Abuo-Rahma, Design, synthesis, docking studies and biological evaluation of novel chalcone derivatives as potential histone deacetylase inhibitors, Bioorganic Chemistry, 72, (2017), 32–41.
  2. Youssif, B. G. M.; Abdelrahman, M. H.; Abdelazeem, A. H.; Abdelgawad, M. A.; Ibrahim, H. M.; Salem, O. I. A.; Mohamed, M. F. A.; Treambleau, L.; Bukhari, S. N. A., Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production. Europ.J. Med. Chem. 2018, 146, 260-273.
  3. Abdelbaset, M. S.; Abuo-Rahma, G. E. A.; Abdelrahman, M. H.; Ramadan, M.; Youssif, B. G. M.; Bukhari, S. N. A.; Mohamed, M. F. A.; Abdel-Aziz, M., Novel pyrrol-2(3H)-ones and pyridazin-3(2H)-ones carrying quinoline scaffold as anti-proliferative tubulin polymerization inhibitors. Bioorg. Chem. 2018, 80, 151-163.

 


2020-02-04 19:06:32 | Keywords Ligustrazine, HDACs Inhibitors;, In silico study, Anticancer agents, Synthesis, , , ,
Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety
INTRODUCTION: Histone deacetylases (HDACs) represent one of the most validated cancer targets. The inhibition of HDACs has been proven to be a successful strategy for the development of novel anticancer candidates. METHODS: This work describes design and synthesis of a new set of HDAC inhibitors ( 7A-C and 8A, B) utilizing ligustrazine as a novel cap moiety, and achieving the ... Read more

Antibacterial and Urease Inhibitory activity of New Piperazinyl N-4 Functionalized Ciprofloxacin-oxadiazoles
This research includes design of new ciprofloxacin bearing oxadiazole at the N-4 piperazinyl for the purpose of having urease inhibitory activity as well as antibacterial activity. Hence, a group of new N-4 piperazinyl oxdiazole derivatives of ciprofloxacin was prepared and characterized using different spectroscopic and analytical techniques including 1H-NMR, 13C-NMR, MS and elemental analysis. Compounds 5b and 5c experienced moderate ... Read more

Recent Prospectives of Anticancer Histone Deacetylase Inhibitors
Histone deacetylases (HDACs) are common targets for cancer therapy as they are expressed in many forms of cancers; several research studies have been introduced discussing the design of small molecules that target this abnormal epigenetic changes developed by HDACs in chromatin. In the past 10 years, HDAC inhibitors have emerged as important agents of interest in clinical trials for several ... Read more

Utilization of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinone as a cap moiety in design of novel histone deacetylase inhibitors
A series of novel 5,6,7,8-Tetrahydro[1]benzothieno[2,3_-d_]pyrimidin-4(3_H_)-one derivatives bearing a hydroxamic acid, 2-aminoanilide and hydrazide moieties as zinc-binding group (ZBG) were designed, synthesized and evaluated for the HDAC inhibition activity and antiproliferative activity. Most of the tested compounds displayed strong to moderate HDAC inhibitory activity. Some of these compounds showed potent anti-proliferative activity against human HepG2, MCF-7 and HCT-116 cell lines. In ... Read more

EGFR inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and docking studies of novel xanthine derivatives carrying chalcone moiety as hybrid molecules
One of the helpful ways to improve the effectiveness of anticancer agents and weaken drug resistance is to use hybrid molecules. therefore, the current study intended to introduce 20 novel xanthine/chalcone hybrids 9-28 of promising anticancer activity. Compounds 10, 11, 13, 14, 16, 20 and 23exhibited potent inhibition of cancer cells growth with IC50 ranging from 1.0±0.1 to 3.5±0.4 μM ... Read more

Task 1
* Arrange the reactivity of the following compounds toward electrophilic aromatic substitution, give reasons? * Read more

task 2
2- Give both the IUPAC and common nomenclature of the following compounds and indicate the type of each alkyl halide? Read more

task 1
* 1- Arrange the reactivity of the following alkyl halide towards SN2 reaction, justify your answer? * Ethyl iodide * Butyl iodide * Methyl iodide * iso-Propyl iodide Read more