Noha Abdelmageed

Lecturer - lecturer

Faculty of Veterinary Medicine

Address: Fculty of veterinary Medicine, pharmacology department



Our mission is to provide quality preclinical and clinical education in pharmacology and therapeutics for veterinary students, to educate and train graduate and postdoctoral biomedical scientists, to advice and train veterinarians to pursue technologies in clinical pharmacology and train the next generation of veterinarians in therapeutics at veterinary health care, to carry out basic research of recognized excellence, and to participate in governance and leadership in faculty of veterinary medicine at south valley university and in appropriate national scientific and professional societies

2020-04-09 01:42:45
chemotherapy (antiparasitic drugs) Read more

2019-02-08 01:05:20 | Keywords Triterpenoids Oleanolic acid , ROS, Mitocan, prostate cancer, Apoptosis, ,
Oleanolic acid methyl ester, a novel cytotoxic mitocan, induces cell cycle arrest and ROS-Mediated cell death in castration-resistant prostate cancer PC-3 cells
Oleanolic acid derivatives exhibit potent anticancer activities against numerous types of cancer. However, the antitumor activity of oleanolic acid methylester (OAME), an oleanolic acid derivative, against prostate cancer has not been studied. Hence, the present work was conducted to study the anticancer activities of OAME. Viability assay showed that treatment of cancer cells with OAME induced a significant cell death ... Read more

2019-02-08 01:08:26 | Keywords Ceramide, P-glycoprotein, Colorectal cancer, tamoxifen, P53,
Tamoxifen magnifies therapeutic impact of ceramide in human colorectal cancer cells independent of p53.
Poor prognosis in patients with later stage colorectal cancer (CRC) necessitates the search for new treatment strategies. Ceramide, because of its role in orchestrating death cascades in cancer cells, is a versatile alternative. Ceramide can be generated by exposure to chemotherapy or ionizing radiation, or it can be administered in the form of short-chain analogs (C6-ceramide). Because intracellular P-glycoprotein (P-gp) ... Read more

2019-02-08 01:34:37 | Keywords Sphingolipid, Acid ceramidase, PSC 833, Ceramide, Pancreatic cancer,
Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells.
PURPOSE Acid ceramidase (AC) occupies an important place in the control of cancer cell proliferation. We tested the influence of AC inhibition on the effects of PSC 833, a P-glycoprotein antagonist with potent ceramide-generating capacity, to determine whether AC could be a therapeutic target in pancreatic cancer. METHODS Ceramide metabolism was followed using 3H-palmitate, and molecular species were determined by ... Read more