amr_hassanegypt

Amr Hassan Moustafa Ahmed

Assistant Professor - Assistant Professor

Faculty of science

Address: Al-Iman Tower, Al-Sharaieh Street, behind the university's dormitory for girls' students, Nasser City - Sohag

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3.	Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies
A series of novel naproxen analogues containing 3-aryl-1,2,4-oxadiazoles moiety (4b-g) and their reaction intermediates aryl carboximidamides moiety (3b-g) was synthesized and evaluated in vitro as dual COXs/15-LOX inhibitors. Compounds 3b-g exhibited superior inhibitory activity than celecoxib as COX-2 inhibitors. Compounds 3b-d and 3g were the most potent COX-2 inhibitors with IC50 range of 6.4 – 8.13 nM and higher selectivity ... Read more

2.	A regioselective and convenient one-pot multicomponent synthesis of polyfunctionalized 4-aryl-2-cyanoimino-3,4-dihydro-1H-pyrido[2,3-d]pyrimidines
A novel series of 5,7-diamino-4-aryl-6-cyano-2-cyanoimino-3,4-dihydro-1H-pyrido[2,3-d]pyrimidines (aryl-CIDHPPMs) 3a–i was prepared via the one-pot four-component reaction of cyanoguanidine with aromatic aldehydes and malononitrile with molar ratio (1:1:2) using sodium methoxide as catalyst. These new polyfunctionlized aryl-CIDHPPMs were also synthesized by a classical route via reaction of cyanoguanidine with the respective arylidenes of malononitrile dimer under the same condition. In the same manner, ... Read more

An Efficient Synthesis of Benzylidene-2-alkoxy-4-aryl-2,3-cycloalkenopyridine-3-carbonitrile Derivatives
An efficient procedure for the synthesis of a novel class of benzylidene-2-alkoxy-4-aryl-6,7-dihydro-5H-cyclopenta[b]pyridine-, -5,6,7,8-tetrahydroquinoline and/or -6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine- 3-carbonitrile was introduced through the one-pot multicomponent reaction of cyclopentanone, cyclohexanone, and/or cycloheptanone with different aromatic aldehydes and malononitrile. The same products were also produced by classical route by the two-component reaction of dibenzylidine cyclopentanone, cyclohexanone, and/or cycloheptanone derivatives with malononitrile. The reactions were achieved ... Read more

2018 | Keywords Dihydrochalcones (DHCs),
Unexpected products from the reaction of chalcones with cyanoguanidine
A new series of unexpected dihydrochalcones DHCs attached with cyanoiminopyrimidine moiety in addition to expected cyanoaminopyrimidines CAMPs were synthesized by efficient and facile method via reaction of cyanoguanidine with chalcone derivatives in the presence of EtONa. Read more

2018 | Keywords Thieno[2, 3-b]thiophene,
New Polymer Syntheses Part 60: A Facile Synthetic Route to Polyamides Based on Thieno[2,3-b]thiophene and Their Corrosion Inhibition Behavior
Polyamides containing thieno[2,3-_b_]thiophene moiety were prepared _via_ a simple polycondensation reaction of the diaminothieno[2,3-_b_]thiophene monomer 1A with different kinds of diacid chlorides (including oxalyl, adipoyl, sebacoyl, isophthaloyl, terephthaloyl, 4,4′-azodibenzoyl, 3,3′-azodibenzoyl, _p_-phenylene diacryloyl) in the presence of LiCl and NMP as a solvent through low-temperature solution polycondensation. The chemical structures of model compound and synthesized polyamides were confirmed by FTIR, nuclear ... Read more

2017 | Keywords naphthyridine,
Synthesis of Some New 1,8-Naphthyridines From N-(7- Chloro-5-Methyl-1,8-Naphthyridine-2-yl)Acetamide and 7-Amino-2-Chloro-4-Methyl-1,8-Naphthyridine
The first parent compound _N_-(7-chloro-5-methyl-1,8-naphthyridine-2-yl)acetamide was reacted with both of ethyl thioglycolate forming ethyl [{7-(acetylamino)-4-methyl-1,8-naphthyridine-2yl} sulfanyl] acetate and ethyl[(-7-amino-4-methyl-1,8-naphthyridine-2yl) sulfanyl] acetate and with thioacetamide to afford _N_-[5-methyl-7-sulfanyl-1,8-naphthyridine-2-yl] acetamide. The last product was used as an intermediate for the synthesis of different novel mercapto derivatives. The second parent compound 7-amino-2-chloro-4-methyl-1,8-naphthyridine was reacted with several active organic compound (e.g. propanedinitrile, diethylpropanedioate, ethylcyanoacetate ... Read more

2017 | Keywords pyridin-2-ylcyanamide,
Detailed Studies of the Alkylation Sides of Pyridin-2-yl and 4,6-Dimethylpyrimidin-2-yl-cyanamides
Pyridin-2-yl- and 4,6-dimethylpyrimidin-2-yl-cyanamides entered into an alkylation reaction in the form of sodium salts. Pyridin-2-yl cyanamide 2 was alkylated at endo-nitrogen atom of pyridine ring, while 4,6-dimethylpyrimidin-2-yl cyanamide 1 was effectively alkylated at exo-nitrogen atom of amino cyanamide group. The alkylation of cyanamides 1 and 2 with phenacylbromide gave the corresponding acetophenone derivatives. As a result of their intramolecular cyclization ... Read more

2017 | Keywords chalcone,
A regioselective and convenient one-pot multicomponent synthesis of 9-amino-3,5- diaryl-4,9-dihydro-5H-[1,2,4]triazolo[5,1-c] [1,2,4]triazepine-8-thiol
An efficient and environment-friendly procedure for the synthesis of a new series of nitrogen bridge-head [1,2,4]triazolo[5,1-_c_][1,2,4]triazepine derivatives through one-pot three-component reaction of polyfunctional triazole with aromatic aldehydes and acetophenone derivatives using alcoholic sodium hydroxide solution. The same new products were prepared in classical route through reaction of triazole with the corresponding chalcones under the same conditions. Read more

2017 | Keywords Cyanoguanidine,
New route for the synthesis of new cyanoimino- and cyanoaminopyrimidines
A novel series of 4-aryl-2-cyanoimino-3,4-dihydro-1_H_-pyrimidines (aryl-CIDHPMs) was synthesized using a new method via the one-pot three-component reaction of cyanoguanidine with malononitrile and aromatic aldehydes using sodium methoxide as catalyst. These new aryl-CIDHPMs were also prepared by a classical route via reaction of cyanoguanidine with the corresponding arylidenemalononitriles under our conditions. In the same manner, the reaction of cyanoguanidine with cyclohexylidenemalononitrile ... Read more

2017 | Keywords 2-aminopyrimidine,
Syntheses of Some New N-Linked Pyimidine-2-amines with Pyrazinopyrimidines, Thienopyrimidines, and Benzazoles via Reactions of Various Nucleophiles with Cyanamides
New heterocycles containing 2-aminopyrimidine moiety linked with pyrazino[1,2-_c_]pyrimidines, thieno[2,3-_d_]pyrimidines, benzimidazoles, benzothiazoles, and benzoxazoles have been prepared by an efficient method starting from _N_-(pyrimidin-2-yl)cyanamides. Read more