Dr. Ahmed Mohammed Abu-Dief Mohammed

Assistant Professor - Assistant professor of Inorganic and Physical Chemistry

Faculty of science

Address: Behind hospital of Sohag University - Ali Ebn Abi Taleb Street


2021 | Keywords Colorectal cancer,
Novel Green Biosynthesis of 5-Fluorouracil Chromium Nanoparticles Using Harpullia Pendula Extract for Treatment of Colorectal Cancer
Colorectal cancer (CRC) is the third major cause of morbidity and mortality worldwide. Hence, many strategies and approaches have been widely developed for cancer treatment. This work prepared and evaluated the antitumor activity of 5-Flurouracil (5-Fu) loaded chromium nanoparticles (5-FuCrNPs). The green biosynthesis approach using Harpullia (H) pendula aqueous extract was conducted for CrNPs preparation that was further loaded with ... Read more

Targeting ctDNA binding and elaborated in-vitro assessments concerning novel Schiff base complexes: Synthesis, characterization, DFT and detailed in-silico confirmation
Two novel complexes for Zn2+ and VO2+ ions, were prepared from tridentate dibasic chelating Schiff base ligand. 1-((3,5-di-_tert_-butyl-2-hydroxybenzylidene)amino)naphthalen-2-ol-5‑sodium sulfonate (DSHN), was the ligand used in this study. Alternative spectral tools were applied to elucidate structural composition of new compounds. Also, geometry optimization for all synthesizes was conducted by Gaussian09 program via DFT method, to obtain optimal structures and essential parameters. ... Read more

Synthesis and characterization of Fe(III), Pd(II) and Cu(II)-thiazole complexes; DFT, pharmacophore modeling, in-vitro assay and DNA binding studies
New pharmacologically active complexes were prepared from Pd (II), Fe (III), and Cu (II)ions with 2-amino-6-oxo-3-(piperidinylamidino)-4-(4methoxyphenyl)-6,7-dihydro-pyrano[2,3-d]-5,7thiazol ligand (MPTP). The ligand acted as neutral bidentate with the metals _via_ NH and NH2 groups. FT-IR spectra, CHN-analysis, TGA, UV–Vis, molar conductance and 1H &13C NMR spectra were used to characterize the new compounds. Also stability constant of MPTP-complexes was identified in solution ... Read more

2021 | Keywords ferrocenyl thiophenol ligand,
Design, synthesis, structural inspection of Pd2+, VO2+, Mn2+, and Zn2+ chelates incorporating ferrocenyl thiophenol ligand: DNA interaction and pharmaceutical studies
Some new transition metal chelates ([M(FSH)2] and [M(FSH) (CH3COO− or NO3−)], where M = Pd2+, VO2+, Mn2+, Zn2+, and cations) incorporating ferrocenyl thiophenol imine ligand (FSH) were prepared. Various spectral and physicochemical studies were performed to elucidate the geometric structure of the investigated compounds. The spectral data of FSH imine ligand and its metal chelates were explained concerning the structural ... Read more

Facile Synthesis, X-ray structure of new Multi-Substituted Aryl Imidazole ligand, Biological Screening and DNA binding of itsCr(III), Fe(III) and Cu(II) coordination  compounds as potential antibiotic and anticancer drugs
A simple highly adjustable and effective synthesis of aryl imidazole ligand HL namely (2‐(1‐butyl‐4,5-diphenyl‐1H‐imidazol‐2‐yl)(4-bromophenol) was discussed where it was prepared by cyclo condensation of 5-Bromo-2-hydroxybenzaldehyde, benzil and Butan-1-amine. Three new Cr(III), Fe(III) and Cu(II) complexes of aryle imidazole ligand were synthesized. The multi-substituted aryl imidazole ligand (HL) and its complexes were characterized by using physicochemical and IR and electronic spectral ... Read more

2020 | Keywords Pd(II), tridentate pyridine,
Chemical, physical and biological properties of Pd(II), V(IV)O, and Ag(I) complexes of N3 tridentate pyridinebased Schiff base ligand
In this study, new N3 tridentate imine ligand, 2,6-diacetylpyridinediphenylhydrazone (DAPH) (L), and its Pd(II), V(IV)O, and Ag(I) complexes were synthesized and characterized via elemental analysis, FT-IR, NMR, molar conductance, and magnetic susceptibility measurements. The obtained data confirmed geometrical structures of Pd(II), Ag(I), and V(IV)O complexes as square planar, tetrahedral, and distorted square pyramidal, respectively. Minimum inhibitory concentrations (MIC) were used ... Read more

Sustainable Nanocomposites for Water Treatment
Nanocomposites are now commonly employed to augment the standard polymeric membrane materials that are used in water treatment processes. In recent years, nanocomposite membranes have greatly attracted the attention of scientists for water treatment applications such as wastewater treatment, water purification, removal of microorganisms, chemical compounds, heavy metals, etc. The incorporation of different nanofillers, such as carbon nanotubes, metal nanocomposites, ... Read more

2020 | Keywords nanoparticles, Cancer Remediation,
Opinion on Nanoparticles for Cancer Remediation
Since the innovation of nanomedicine decades ago, significant advances have been made, especially with cancer as an objective. Nanoparticles in cancer remediation intends to cover different important aspects in this field including development of nanocarrier, delivery of gene, intrinsically active nanoparticles (NPs), microenvironment of tumor, toxicity, and immunology. The mostly applied biocompatible nanocarriers in clinical experiments are lipid, polymer, and ... Read more

Development of Metal Oxide Nanoparticles as Semiconductors
The physical and chemical properties of semiconductor materials change drastically when its size is reduced to nanoscale due to their large surface area or quantum size effect. Metal oxide (MOx) semiconducting nanostructures hold the potential for playing a critical role in the development of a new platform for renewable energies, including energy conversion and storage through photovoltaic effect, solar fuels, ... Read more

DNA Interaction of Drug Molecules for Cancer Treatment
The deoxyribonucleic acid (DNA) is the molecule of life that controls all the chemical changes that take place in cells. It is the molecular target for many of the drugs that are used in cancer therapeutics, and is viewed as a non-specific target of cytotoxic agents. The interaction of drugs with DNA is among the most important aspects of biological ... Read more