Dr. Ahmed Mohamed Abu-Dief

Assistant Professor - Assistant professor of Inorganic and Physical Chemistry

Faculty of science

Address: Behind hospital of Sohag University - Ali Ebn Abi Taleb Street


Tailoring of Novel Azithromycin-Loaded Zinc Oxide Nanoparticles for Wound Healing
Skin is the largest mechanical barrier against invading pathogens. Following skin injury, the healing process immediately starts to regenerate the damaged tissues and to avoid complications that usually include colonization by pathogenic bacteria, leading to fever and sepsis, which further impairs and complicates the healing process. So, there is an urgent need to develop a novel pharmaceutical material that promotes ... Read more

2022 | Keywords (AgNPs,
Green Biogenic Synthesis of Silver Nanoparticles Using Aqueous Extract of Moringa Oleifera: Access to a Powerful Antimicrobial, Anticancer, Pesticidal and Catalytic Agents
In this study, we look into the biogenic synthesis of (AgNPs) utilizing a simple and environmentally friendly method based on an aqueous extract of _Moringa Oleifera_ (MO). The synthesized MOAgNPs were characterized using a UV–Visible spectrophotometry, X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectra and TEM image which confirmed the spherical shape of MOAgNPs with particle size range of 5–50 ... Read more

2022 | Keywords SARS-CoV-2,
Using Safe Calculated Low Power of Electrons to Cut, Analyze and Exterminate the Outer and Inner Biological Elements of SARS-CoV-2, MERS-CoV-2 and Influenza viruses in Vitro
Background: The treatment of pneumonia viruses with antiviral drugs produced mild to severe side effects until the immune system worked against the invaded virus. Objective: Therefore, it is crucial to develop an efficient alternative therapy with lower side effects against infection of pneumonia viruses. Methods: We hereby designated a novel device termed a a Life Restoration Device (LRD to produce ... Read more

2022 | Keywords DNA interaction,
Synthesis, Structural elucidation, DFT calculation, Biological studies and DNA Interaction of Some Aryl hydrazone Cr3+, Fe3+, and Cu2+ Chelates
The current research focuses on the treatment of Cr(III), Fe(III) and Cu(II) metal ions with aryl hydrazone ligand named (E)-4-(((diphenylmethylene)hydrazono)methyl)benzene-1,3-diol (DPHB) to afford four novel solid complexes with high yields. Different characterization approaches, including infrared, UV-visible, and NMR spectroscopies, elemental analyses, and thermal gravimetric analysis (TGA), revealed that all mononuclear crystalline metal chelates with good thermal stability had a six-coordination ... Read more

2021 | Keywords Colorectal cancer,
Novel Green Biosynthesis of 5-Fluorouracil Chromium Nanoparticles Using Harpullia Pendula Extract for Treatment of Colorectal Cancer
Colorectal cancer (CRC) is the third major cause of morbidity and mortality worldwide. Hence, many strategies and approaches have been widely developed for cancer treatment. This work prepared and evaluated the antitumor activity of 5-Flurouracil (5-Fu) loaded chromium nanoparticles (5-FuCrNPs). The green biosynthesis approach using Harpullia (H) pendula aqueous extract was conducted for CrNPs preparation that was further loaded with ... Read more

Targeting ctDNA binding and elaborated in-vitro assessments concerning novel Schiff base complexes: Synthesis, characterization, DFT and detailed in-silico confirmation
Two novel complexes for Zn2+ and VO2+ ions, were prepared from tridentate dibasic chelating Schiff base ligand. 1-((3,5-di-_tert_-butyl-2-hydroxybenzylidene)amino)naphthalen-2-ol-5‑sodium sulfonate (DSHN), was the ligand used in this study. Alternative spectral tools were applied to elucidate structural composition of new compounds. Also, geometry optimization for all synthesizes was conducted by Gaussian09 program via DFT method, to obtain optimal structures and essential parameters. ... Read more

Synthesis and characterization of Fe(III), Pd(II) and Cu(II)-thiazole complexes; DFT, pharmacophore modeling, in-vitro assay and DNA binding studies
New pharmacologically active complexes were prepared from Pd (II), Fe (III), and Cu (II)ions with 2-amino-6-oxo-3-(piperidinylamidino)-4-(4methoxyphenyl)-6,7-dihydro-pyrano[2,3-d]-5,7thiazol ligand (MPTP). The ligand acted as neutral bidentate with the metals _via_ NH and NH2 groups. FT-IR spectra, CHN-analysis, TGA, UV–Vis, molar conductance and 1H &13C NMR spectra were used to characterize the new compounds. Also stability constant of MPTP-complexes was identified in solution ... Read more

2021 | Keywords ferrocenyl thiophenol ligand,
Design, synthesis, structural inspection of Pd2+, VO2+, Mn2+, and Zn2+ chelates incorporating ferrocenyl thiophenol ligand: DNA interaction and pharmaceutical studies
Some new transition metal chelates ([M(FSH)2] and [M(FSH) (CH3COO− or NO3−)], where M = Pd2+, VO2+, Mn2+, Zn2+, and cations) incorporating ferrocenyl thiophenol imine ligand (FSH) were prepared. Various spectral and physicochemical studies were performed to elucidate the geometric structure of the investigated compounds. The spectral data of FSH imine ligand and its metal chelates were explained concerning the structural ... Read more

2021 | Keywords Manfort, infertility, sperm qu,
Manfort: A dietary supplement for semen parameters quality improvement in low sperm count and azoospermia patients
BACKGROUND: The production of healthy sperms from testicular tissues which able to successfully fertilize the mature egg is the main target of the recent studies. Recently dietary supplements composed from multi-natural products extracted from medicinal herbs are used for sperm parameters improvement compared with chemically-based synthesized drugs. This traditional method of treatment is safe, effective and low costed compared with ... Read more

Synthesis and structural elucidation for new pyrano thiazole complexes: Biological screening and effects on DNA through in-vitro and in-silico approaches
Novel bioactive complexes were prepared from Cu(II), Fe(III) and Pd(II) ions with pyrano thiazole derivative (PTP) [2-amino-6-oxo-3-(piperidinylamidino)-4-phenyl-6,7-dihydro-pyrano[2,3-d]-5,7-thiazol]. CHN, FT-IR, UV–Vis, 1H NMR, 13C NMR, molar conductance and TGA results have been used to determine the chemical formulae of new compounds. Accordingly, the octahedral geometry was proposed for the complexes except PTPPd complex (square-planer). The ligand acts as a neutral bidentate ... Read more