Omar Khadrawy

Teadching-Assistant -

Faculty of Veterinary Medicine

Address: Sohag


2108 | Keywords Nrf2 pathway, bovine embryo,
Quercetin protects bovine pre-implantation embryos against oxidative stress via activation of Nrf2 signaling pathway
High atmospheric oxygen level during _in vitro_ embryo culture system is reported to induce oxidative stress, leading to an increased intracellular reactive oxygen species (ROS) accumulation and lower the quality and development of the embryos. The Nrf2 is a redox sensitive transcription factor, which regulates the antioxidant machinery against oxidative stress in bovine pre-implantation embryos (Amin _et al._ 2014 Mol. ... Read more

Endogenous and Exogenous Modulation of Nrf2 Mediated Oxidative Stress Response in Bovine Granulosa Cells: Potential Implication for Ovarian Function
Nrf2 is a redox sensitive transcription factor regulating the expression of antioxidant genes as defense mechanism against various stressors. The aim of this study is to investigate the potential role of noncoding miRNAs as endogenous and quercetin as exogenous regulators of Nrf2 pathway in bovine granulosa cells. For this cultured granulosa cells were used for modulation of miRNAs (miR-28, 153 ... Read more