eman_shalabi

Eman Muhammad Salah El-Deen Muhammad Shalabi

Professor - Professor Emeritus of Pathology

Faculty of medicine

Address: القوصية - محافظة أسيوط

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Expression of p53, bcl-2, bax and bcl-xl in ductal carcinoma in situ (DCIS) of the breast.

2014 | Keywords o breast, DCIS, Bcl-xl, Bax, Bcl-2, P53,
Expression of p53, bcl-2, bax and bcl-xl in ductal carcinoma in situ (DCIS) of the breast.
BACKGROUND: DCIS is a malignant proliferation of mammary ductal epithelial cells without invasion beyond the basement membrane. Bcl-2, bax, bcl-xl and p53 are implicated in regulation of apoptosis. This study aimed to clarify the role of these gene products in DCIC. MATERIALS AND METHODS: Immunohistochemical staining of 13 cases of DCIS with bcl-2, bax, bcl-xl and p53 was performed. RESULTS: ... Read more

Correlation of Microvessel density (MVD) and Proliferation Index (PI) with Clinico-pathological Parameters in Breast Carcinoma

2013 | Keywords Breast Carcinoma, Clinico-pathological, MVD,
Correlation of Microvessel density (MVD) and Proliferation Index (PI) with Clinico-pathological Parameters in Breast Carcinoma
BACKGROUND: One of the greatest challenges in breast cancer management is to accurately predict the outcome for each patient. Microvessel density (MVD) correlated closely with increasing number of tumor cells shed into the bloodstream and development of metastasis. Because proliferation status closely correlates with tumor aggressiveness, proliferation index (PI) is considered as an established prognostic marker for various tumors. WE ... Read more

Immunohistochemical Cyclooxygenase-2 (COX-2) and P53 expression in Breast Carcinoma with Correlation to Clinico-pathological Parameters

2013 | Keywords Clinico-pathological Parameters, Breast Carcinoma, P53, COX-2,
Immunohistochemical Cyclooxygenase-2 (COX-2) and P53 expression in Breast Carcinoma with Correlation to Clinico-pathological Parameters
BACKGROUND/AIMS: Breast cancer is the most common cancer in Egyptian women. This study aims to: 1. Evaluate COX-2 and p53 expressions in the successive steps of breast carcinogenesis. 2. Determine the correlation between COX-2 and p53 with the clinico-pathological parameters in ductal breast carcinoma. PATIENTS AND METHODS: This study included 74 specimens of breast lesions. Data about patient’s age, tumor ... Read more

Immunohistochemical Cyclooxygenase-2 (COX-2) and CD31 Expression in Breast Carcinoma with Correlation to Clinico-pathological Parameters

2013 | Keywords COX-2, CD31, Breast Carcinoma, Clinico-pathological Parameters,
Immunohistochemical Cyclooxygenase-2 (COX-2) and CD31 Expression in Breast Carcinoma with Correlation to Clinico-pathological Parameters
BACKGROUND: Breast cancer is the most common cancer in Egyptian women. COX-2 seems to be involved in malignant transformation and tumor progression by affecting cell proliferation, mitosis, cell adhesion, apoptosis, immune surveillance, and angiogenesis. Angiogenesis is an important key step in tumor progression. Microvascular density (MVD), a surrogate marker of angiogenesis can be assessed by CD31 staining. AIMS This study ... Read more

Evaluation of the Proliferation Index and p53 Protein Expression in Preinvasive and Invasive Breast Carcinoma

2013 | Keywords P53, Expression, Breast Carcinoma,
Evaluation of the Proliferation Index and p53 Protein Expression in Preinvasive and Invasive Breast Carcinoma
BACKGROUND: Breast cancer is the most frequently diagnosed cancer and the most common cause of cancer deaths in women worldwide. Ki67 is a biomarker that reflects cell proliferation. Despite a clear understanding of the structure and properties of this protein, its functional role remains elusive. Gene expression alteration confers the potential for invasive growth in the preinvasive stages of breast ... Read more

PROLIFERATIVE INDEX AND P53 EXPRESSION IN BREAST CARCINOMA AND THEIR CORRELATION TO CLINICO-PATHOLOGICAL PARAMETERS

2013 | Keywords DCIS, IDC, Ki67, P53,
PROLIFERATIVE INDEX AND P53 EXPRESSION IN BREAST CARCINOMA AND THEIR CORRELATION TO CLINICO-PATHOLOGICAL PARAMETERS
BACKGROUND: Breast cancer is the most frequently diagnosed cancer and the most common cause of cancer deaths in women worldwide. Ki67 is a biomarker that reflects cell proliferation. Despite a clear understanding of the structure and properties of this protein, its functional role remains elusive. Gene expression alteration confers the potential for invasive growth in the preinvasive stages of breast ... Read more

Predictors of Sustained Virologic Response to Interferon Therapy in Chronic Hepatitis C: Role of Hepatic Progenitor Cells.

2013 | Keywords Interferon Therapy, Chronic Hepatitis C, HPCs,
Predictors of Sustained Virologic Response to Interferon Therapy in Chronic Hepatitis C: Role of Hepatic Progenitor Cells.
INTRODUCTION: Predictors of SVR to pegylated interferon (PEG-INF) alfa-2a and ribavirin (RBV) therapy in chronic HCV infected patients is very important for therapy. Increased HPCs in HCV-infected patients was correlated with increasing fibrosis and response to treatment. HPCs was detected in the liver by immunohistochemical expressions of cytokeratin (CK) 7 and CK19. AIMS &METHODS: Evaluation of the response rate to ... Read more

Predictors of Sustained Virologic Response to Interferon Therapy in Chronic Hepatitis C: Role of Hepatic Progenitor Cells

2013 | Keywords HPCs, interferone therapy,
Predictors of Sustained Virologic Response to Interferon Therapy in Chronic Hepatitis C: Role of Hepatic Progenitor Cells
INTRODUCTION: Studying the predictors of SVR to pegylated interferon (PEG-INF) alfa-2a and ribavirin (RBV) therapy in chronic HCV infected patients is crucial for selecting those who would benefit most from therapy. Increased HPCs in HCV-infected patients were shown to be correlated with increasing fibrosis and response to treatment. HPCs could be detected in the liver by immunohistochemical expressions of cytokeratin ... Read more

Evaluation of some Histochemical and Immunohistochemical Criteria of Round Cell Tumors of Bone (RCTB)

2012 | Keywords Histochemical, Immunohistochemical Criteria, Round Cell Tumors, Bone,
Evaluation of some Histochemical and Immunohistochemical Criteria of Round Cell Tumors of Bone (RCTB)
BACKGROUND/AIMS: Differential diagnosis of RCTB; Ewing sarcoma, small cell osteosarcoma, mesenchymal chondrosarcoma, osteoblastoma, chondroblastom, primary bone lymphoma and multiple myeloma is still challenging. Given the significant differences in treatment, accurate diagnosis is imperative. This study aimed to evaluate some histochemical and immunohistochemical criteria of RCTB. SUBJECTS AND METHODS: PAS, CD99, CD138, osteocalcin, and LCA were evaluated in 113 cases of ... Read more

Use of Cyclo-oxygenase (COX)-2 Expression and Ki-67-Labeling Index (LI) in the Differntiation between Osteoblastoma and Osteosarcoma

2012 | Keywords Osteosarcoma, Osteoblastoma, Ki-67, COX-2,
Use of Cyclo-oxygenase (COX)-2 Expression and Ki-67-Labeling Index (LI) in the Differntiation between Osteoblastoma and Osteosarcoma
BACKGROUND: Osteoblastoma and osteosarcoma are primary bone forming tumors that show different clinical behavior and radiological/pathological features. In the majority of cases the two entities may easily be separated. Occasionally, however osteoblastoma may resemble osteosarcoma histologically, and the differential diagnosis between aggressive osteoblastoma and low grade osteosarcoma may be very difficult or even impossible on a small biopsy sample. AIMS: ... Read more