eman_shalabi

Eman Muhammad Salah El-Deen Muhammad Shalabi

Professor - Professor Emeritus of Pathology

Faculty of medicine

Address: القوصية - محافظة أسيوط

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Chronic A1 and A2b adenosine receptor blockade improves diabetes and attenuates renal and cardiac histopathology in animals with the metabolic syndrome

| Keywords adenosine receptors, Diabetes, ,
Chronic A1 and A2b adenosine receptor blockade improves diabetes and attenuates renal and cardiac histopathology in animals with the metabolic syndrome
Few therapies are known to enhance diastolic function. Systemic administration of natriuretlc peptldes (NP) improves diastolic function. However, this may be due to effects on load, rather than a direct myocardlal action. We generated mice with acar-disc-specific (a-MHC promoter) gain-of-function mutation (GoF, HCAT E974A) in the natriuretic peptide A receptor (NPRA) resulting in myocyte-specific constitutive NPRA activation. We hypothesized that ... Read more

Chronic A1 and A2b adenosine receptor blockade improve diabetes and attenuates renal and cardiac histopathology in animals with the metabolic syndrome.

| Keywords
Chronic A1 and A2b adenosine receptor blockade improve diabetes and attenuates renal and cardiac histopathology in animals with the metabolic syndrome.
PURPOSE: In left ventricular dysfunction, shortterm A1 adenosine receptor blockade causes diuresis/natriuresis without altering potassium excretion and, in contrast to loop diuretics, improves renal function. Blockade of the A2b adenosine receptor has an antidiabetic effect. This study was done to examine the long-term efficacy and safety of BG9928, a novel, orally active, and highly potent A1 adenosine receptor antagonist with ... Read more