eman_shalabi

Eman Muhammad Salah El-Deen Muhammad Shalabi

Professor - Professor Emeritus of Pathology

Faculty of medicine

Address: القوصية - محافظة أسيوط

23

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2012 | Keywords endometr, B-Catenin, PCNA, TEN,
The value of PTEN, PCNA and B-Catenin to differentiate between endometrial hyperplasia and endometrial adenocarcinoma
Endometrial carcinoma is one of the most common malignancies of female genital tract. Well differentiated endometrioid carcinoma is histologically similar to complex atypical endometrial hyperplasia and sometimes it is difficult to differentiate between them. We hypothesis that the use of PTEN the tumor suppressor gene, PCNA a marker of proliferation and B-Catenin oncogene may be of value to differentiate well ... Read more

2012 | Keywords FNAC, Breast Lumps,
Validity of Fine Needle Aspiration Cytology (FNAC) in Diagnosis of Breast Lumps in Upper Egypt
INTRODUCTION: A palpable breast lump is a common diagnostic problem both to the general practitioner and to the surgeon, which needs rapid definitive diagnosis at the busy Outpatient Clinic. Fine needle aspiration cytology (FNAC) has become the first choice for diagnosis after initial clinical evaluation. AIM OF THE WORK: This study was designed to investigate the validity of FNAC in ... Read more

2012 | Keywords IL-8, COX-2,
Expression of Cyclooxygenase-2 (COX-2) and Interleukin-8 (IL-8) in H. pylori Gastritis; A Study on Diagnostic Methods and Pathological Effects of H. pylori Infection in Dyspeptic Patients
_BACKGROUND__ H. pylori_ infection causes diverse clinical outcomes, including dyspepsia, peptic ulceration, gastric carcinoma and mucosa associated lymphoid tissue (MALT) lymphoma. Up-regulation of COX-2 has been observed in _H. pylori_ gastritis in response to inflammatory cytokines. IL-8 is a major activator for neutrophils which contribute to mucosal damage in _H. pylori_ infected patients. A wide-spread use of non-invasive simple diagnostic ... Read more

Semiquantitative Smoothelin Expression in Detection of Muscle Invasion in Transurethral Resection and Cystectomy Specimens in Cases of Urinary Bladder Carcinoma
ABSTRACT OBJECTIVES: To examine the usefulness of smoothelin - a new immunohistochemical (IHC) marker that is expressed predominantly in visceral smooth muscle - in recognizing muscularis propria (MP) in transurethral resection (TUR) and matched cystectomy specimens and to compare the pattern of its expression in muscularis mucosae (MM) and MP in radical cystectomy specimens. METHODS: IHC staining for smoothelin was ... Read more

Immunohistochemical expression of phosphatase and tensin homolog in endometrial hyperplasia and carcinoma
Introduction: The phosphatase and tensin homolog (PTEN) gene is localized on chromosome 10q23. It is a tumor suppressor gene that inhibits cell proliferation by regulating intracellular signaling pathways, and this activity can be abolished by mutations of the PTEN gene. PTEN is frequently mutated in a wide range of human tumors. Aim of the study: In this study, we evaluated ... Read more

2011 | Keywords Enalapril, rosiglitazone, Diabetic,
Diabetic nephropathy and long-term treatment effects of rosiglitazone and enalapril in obese ZSF1 rats
Diabetic nephropathy (DN) is a major cause of end-stage renal disease. Yet the pathogenic mechanisms underlying the development of DN are not fully defined, partially due to lack of suitable models that mimic the complex pathogenesis of renal disease in diabetic patients. In this study, we describe early and late renal manifestations of DN and renal responses to long-term treatments ... Read more

Serum Prohepcidin, Iron and Hepatic Iron Status in Chronic Hepatitis C in Egyptian Patients
Abstract Background/Aims: Patients with chronic hepatitis C (CHC) often have increased liver iron. Hepcidin has recently emerged as a key regulator for iron homeostasis. Therefore, we aimed to study the relationship between serum prohepcidin, serum iron indices, hepatic necro-inflammation, fibrosis and hepatic iron density and to determine the predictors of advanced fibrosis in those patients. Subjects and methods: Fifty CHC ... Read more

The Role of Hepatic Progenitor Cells (HPCs) and the Predictors of Sustained Virological Response (SVR) to Interferon Therapy in Chronic Hepatitis C Infected Patients
ABSTRACT BACKGROUND: Studying the predictors of SVR to pegylated interferon (PEG-INF) alfa-2a and ribavirin (RBV) therapy in chronic hepatitis C-infected patients is crucial for selecting those who would benefit from therapy. Increasing HPCs in hepatitis C-infected patients were shown to be correlated with increased fibrosis and response to therapy. HPCs could be detected in the liver by immunohistochemical expressions of ... Read more

Urocortin and cytokines in gastric mucosa: Relationship to inflammatory activity before and after medical eradication of Helicobacter Pylori
BACKGROUND AND AIMS: There is a debate whether the majority of gastritis mucosal injury occurs as a direct effect of _H. pylori_ infection or as a result of immune cell damage from abundant mediators of inflammatory response. Recently, Urocortin (UCN) has emerged as a mediator of gastrointestinal (GI) responses to noxious stimuli. Interleukins-1β (IL-1β) and interleukin-10 (IL-10) may play important ... Read more

2011 | Keywords Apoptosis, Breast Carcinoma, Bax, Bcl-xl,
Studying of Apoptosis in Breast Carcinoma; Immunohistochemical Evaluation of Pro- and Anti-apoptotic Gene Products Bax and Bcl-xl
Cancer cells acquire their hallmarks of malignancy through the accumulation of gene activation and inactivation over long periods of time. Gene expression studies offer the greatest promise for refining prognostication in breast cancer. For breast cancer, this multistep process may manifest itself as a sequence of pathologically defined stages. Dys-regulation of apoptosis overrides many of the normal checkpoint pathways and ... Read more