Tympanomastoid cholesteatoma has no accepted staging or scoring system up till now. Many classifications/staging were adopted worldwide; yet, failed to gain acceptance. We adopted a newly designed, objective, broad, decisive scoring system for all types of tympanomastoid cholesteatoma that focused on the basic biologic behavior of this serious disease to cover all the black spots in the previous scoring and ... Read more

OBJECTIVES: Cholesteatoma is a nonneoplastic destructive lesion of the temporal bone with debated pathogenesis and bone resorptive mechanism. Both molecular and cellular events chiefly master its activity. Continued research is necessary to clarify factors related to its aggressiveness. We aimed to investigate the expression of Ki-67, cytokeratin 13 (CK13) and cytokeratin 17 (CK17) in acquired nonrecurrent human cholesteatoma and correlate ... Read more

Objective: To correlate the characteristics of type B tympanogram with the type of middle ear fluid in children suffering from persistent OME. Methodology: A prospective study was conducted on children with persistent OME for more than 3 months who failed to respond to medical treatment with type B tympanogram in one or both ears, and were candidate for myringotomy. The ... Read more

INTRODUCTION: Allergic fungal rhinosinusitis (AFRS) is a noninvasive type of fungal rhinosinusitis (FRS) that is diagnosed by fulfilling five diagnostic criteria. OBJECTIVES: We aimed to study the fungal etiology of AFRS and to evaluate the prevalence of AFRS among patients with CRS with nasal polyposis (CRSwNP) that underwent endoscopic sinus surgery (ESS) at Sohag University Hospital. PATIENTS AND METHODS: A ... Read more

Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed ... Read more

BACKGROUND: Cholesteatoma consists of keratinizing squamous epithelium, granulation tissue and keratin plugs. The pathogenesis of cholesteatoma may be related to alterations in the stromal immune cell infiltrate. OBJECTIVE: To examine the immunophenotypic characteristics of the immune cell infiltrate in invasive cholesteatomas. MATERIALS AND METHODS: This study included 12 patients with invasive cholesteatomas causing wide bone erosion of the mastoid, middle ... Read more

To develop a molecular pattern that might help in understanding carcinogenesis of postcricoid carcinoma (PCC) on top of Plummer-Vinson syndrome (PVS) in a prospective controlled study. Twenty-four patients with PVS were diagnosed and followed up over a 4 year period, during which eight of them showed malignant change to PCC. Twenty volunteers free of neoplastic diseases were included as a ... Read more

OBJECTIVE: To compare the gross and microscopic appearance of antrochoanal polyps associated with recurrent epistaxis, with those with a more typical presentation. DESIGN: Prospective, controlled study. METHODS: All patients underwent clinical and endoscopic examination, computed tomography scanning, and examination under anaesthesia, in order to detect the gross diagnostic criteria for antrochoanal polyp. Histological findings on light microscopy were compared for ... Read more

OBJECTIVES: We compared histologic findings on light microscopy of viscid secretions found in association with nasal polyps with those found in patients with chronic sinusitis without polyposis (CSWP). The differences might further understanding of nasal polyp pathogenesis. METHODS: In a prospective controlled study, viscid secretions found in association with nasal polyps were collected at endoscopic sinus surgery. Retained secretions in ... Read more

Objective: to highlight the essential points in diagnosis and management of head and neck epidermoid/dermoid cysts. Design: A retrospective design was followed for the study. Methods: The study included all patients with epidermoid/dermoid cysts presented to the ENT Department over a 7 year's period. Diagnosis was based on history taking, full clinical examination, ultrasonographic examination of the lesion. All cases ... Read more