Ghada Galal

Professor - Head of Tropical Medicine and Gastroenterology Department

Faculty of medicine

Address: Sohag, Egypt


1997 | Keywords H. pylori gastric guice,
Isolation of H. pylori from gastric juice
INTRODUCTION: It has been suggested that _H. pylor_i could be transmitted through vomitus. _H. pylor_i must be able to survive in gastric juice for this to be possible. We studied the ability of the organism to survive in gastric juice outside the human body and identified factors affecting this. METHODS: _H. pylori_ positive subjects (CLO testTM) were enrolled from all ... Read more

Clinical Utility of Simple Fibrosis Markers in Prediction of  Oesophageal Varices in Chronic Hepatitis C Patients with Advanced Fibrosis
_Background and Aims:_ Oesophageal varices (OV) are the most common complication of liver cirrhosis. However, no available data exist on the prevalence and the laboratory predictors of OV in chronic hepatitis C (CHC) Egyptian patients with bridging fibrosis or cirrhosis. Therefore, we aimed to investigate the frequency of OV in these patients and to assess whether simple non-invasive serum fibrosis ... Read more

Non-Invasive Assessment Of Liver Fibrosis In Chronic Hepatitis C Patients
BACKGROUND: The gold standard for assessment of liver fibrosis is liver biopsy, which is invasive and may rarely results in complications. Therefore, searching for alternative, accurate non-invasive parameters to evaluate the presence and degree of liver fibrosis is needed for prediction of prognosis and planning treatment of chronic hepatitis C (CHC) patients. AIM: To examine if serum laboratory markers combined ... Read more

Comparative Study: Valsartan versus Propranolol in Portal Hypertensive Cirrhotic Patients
BACKGROUND: Angiotensin II (A-II) is considered a potential mediator of intrahepatic portal hypertension because its plasma level is elevated in cirrhotic patients. Valsartan-A II blocker- is being tested for use as a portal pressure reducing drug. AIM: To compare haemodynamic changes of 1 week and 1 month treatment with valsartan versus propranolol in cirrhotic portal hypertensive patients. PATIENTS AND METHODS: ... Read more

| Keywords HCV, semen,
Semen and hormonal parameters in men with chronic hepatitis C infection
Male patients with chronic hepatitis C virus (HCV) infection (n ¼ 57) demonstrated a statistically significant decrease in semen volume, sperm count, and progressive sperm motility and a statistically significant increase in abnormal sperm morphology compared with healthy controls (n ¼ 40). The duration of the HCV infection was negatively correlated with semen volume and sperm motility where the HCV ... Read more

Can serum fibrosis markers predict medium/large oesophageal varices in patients with liver cirrhosis?
Background and study aims: Non-invasive predictors of medium/large oesophageal varices (LOVs) could reduce the number of screening endoscopies. As portal hypertension is a consequence of liver fibrosis, serum fibrosis markers were evaluated together with other variables as possible non-invasive predictors of medium OV/LOV. Patients and methods: A total of 154 cirrhotic patients with splenomegaly and 30 healthy control subjects were ... Read more

| Keywords liver cirrhosis,
Monocyte-platelet aggregates and platelet micro-particles in patients with post-hepatitic liver cirrhosis
Introduction: Monocytes are the cells that play a crucial role in the pathogenesis of liver damage and liver cirrhosis (LC), and as platelets, by connecting hemostasis and inflammatory processes, participate in pathogenesis of chronic liver diseases, we aimed to investigate the presence of monocyte-platelet aggregates and platelet micro-particles (PMPs) and their role in LC. Patients and methods: The study included ... Read more

| Keywords Prohepcidin, hepatic iron,
Background/Aims: Patients with chronic hepatitis C (CHC) often have increased liver iron. Hepcidin has recently emerged as a key regulator for iron homeostasis. Therefore, we aimed to study the relationship between serum prohepcidin, serum iron indices, hepatic necro-inflammation, fibrosis and hepatic iron density and to determine the predictors of advanced fibrosis in these patients. Subjects and methods: Fifty CHC treatment ... Read more

| Keywords Egypt, HCV,
Genetic Variability of Hepatitis C Virus in South Egypt and Its Possible Clinical Implication
Egypt is one of the countries with very high rates of hepatitis C virus (HCV) related morbidity and mortality. However, little is known about geographical and clinical differences in genetic variability of HCV in Egypt. Using direct sequencing and phylogenetic analysis of partial core/E1 and NS5B regions of the HCV genome, HCV genotype/subtype was determined in 129 HCVinfected patients residing ... Read more