Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. In laboratory animal models, diethylnitrosamine (DENA) is a well-known agent that has a potent hepatocarcinogenic effect that is used to induce HCC. As curcumin has a potent anti-inflammatory effect with strong therapeutic potential against a variety of cancers, our present study aims to investigate its curative effects and the ... إقراء المزيد

Tumor necrosis factor-α (TNF-α) polymorphism has been suggested to play an important role in the pathogenesis of non alcoholic fatty liver disease (NFALD), and known to be a mediator of insulin resistance. Aim of the work: to investigate the influence of G 308 A (allele TNFA) & G 238 A (allele TNF2) TNF -α polymorphisms and its relationship with insulin ... إقراء المزيد

Iron overload causes iron deposition and accumulation in the liver, heart, skin, and other tissues resulting in serious tissue damages. Signifcant blood clearance from iron and ferritin using wet cupping therapy (WCT) has been reported. WCT is an excretory form of treatment that needs more research efforts. WCT is an available, safe, simple, economic, and time-saving outpatient modality of treatment ... إقراء المزيد

Phenylketonuria (PKU) is one of the commonest inborn error of metabolism, it is an autosomal recessive metabolic genetic disorder characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it nonfunctional. The diagnosis of this disorder can be confirmed by analysis of urine components. The present study aimed to assess the prevalence of PKU among ... إقراء المزيد

Cancer cells undergo an increased steady-state ROS condition compared to normal cells. Among the major metabolic differences between cancer cells and normal cells is the dependence of cancer cells on glycolysis as a major source of energy even in the presence of oxygen (Warburg effect). In Warburg effect, glucose is catabolized to lactate that is extruded through monocarboxylate transporters to ... إقراء المزيد

Gastric-colon cancer is a complex, multi-stage disease involving deregulation of different signaling cascades. Tis study was conducted to determine the extent of apoptosis, angiogenesis, inflammation, and oxidative stress in patients with gastric-colon cancers. Plasma levels of soluble (s) Fas, bcl-2 as antiapoptotic indices; cathepsin D (CD), calpain I and II as proteolytic, apoptotic indices; nitric oxide (NO), lipid peroxides (LPER) ... إقراء المزيد

Aim: This case control study aimed to investigate relationship between appetite hormones (ghrelin and leptin) and body mass index (BMI), insulin and oxidative stress in simple obese and type 2 diabetes (T2DM) obese patients. Methods: Thirty healthy controls; 30 simple obese and 30 T2DM obese patients were enrolled. Demographic and clinical data of all participants were reported. Serum levels of ... إقراء المزيد

Background: Glucose intolerance occurs frequently in patients with liver cirrhosis. However, few studies have assessed its prognostic value in patients with liver cirrhosis. Aim: To evaluate the importance of oral glucose tolerance test (OGTT), insulinlike growth factor-1 (IGF-1) and serum transferrin (TRF) in prediction of disease outcome in patients with post-hepatitic liver cirrhosis. Methods: Seventyfour patients with posthepatitic liver cirrhosis ... إقراء المزيد

Inhalation of crystalline silica has long been associated with lung disease. The rate of disease progression i.e. acute, accelerated or chronic silicosis seems to depend on the rate of deposition as well as the total burden of crystalline silica in the lung. Despite intensive studies, yet little is known about the crucial cellular and molecular mechanisms that initiate and propagate ... إقراء المزيد

Background: Oxidative stress is blamed in the pathogenesis of pre-eclampsia. However, it is less clear what effect gestational antioxidants would have on pre-eclampsia associated coagulopathy, and on neonatal outcome. Aim of the study: To investigate the effect of antioxidants supplementation on coagulopathy during pre-eclampsia and to evaluate maternal and neonatal outcome. Patients and Methods: The study was performed as a ... إقراء المزيد