The JC virus (JCV) infects a large proportion of the population world wide andcan cause progressive multifocal leucoencephalopathy in the context ofimmunodeficiency. Recent reports provide evidence that it may also be oncogenic. Here, JCV was examined by targeting its T-antigen in lung carcinomas (n=103) and normal lung tissues (n=18) by nested-PCR followed by Southern blot, real-time PCR, immunohistochemistry, in situ ... Read more

Interleukin-10 (IL-10), an anti-inflammatory cytokine, has been shown to inhibit osteoclast formation and bone resorption in rat and mouse systems. However, the precise intracellular mechanism(s) of this action remains unclear. The aim ofthis study was to clarify the role of IL-10 in the regulation of critical transcription factors involved in osteoclastogenesis. A RAW264.7 macrophage cell line, which constitutively expressed IL-10 ... Read more

DETECTION OF THE JC VIRUS GENOME IN LUNG CANCERS: POSSIBLE ROLE OF THE T-ANTIGEN IN LUNGONCOGENESIS.DETECTION OF THE JC VIRUS GENOME IN LUNG CANCERS: POSSIBLE ROLE OF THE T-ANTIGEN IN LUNGONCOGENESIS.DETECTION OF THE JC VIRUS GENOME IN LUNG CANCERS: POSSIBLE ROLE OF THE T-ANTIGEN IN LUNGONCOGENESIS.DETECTION OF THE JC VIRUS GENOME IN LUNG CANCERS: POSSIBLE ROLE OF THE T-ANTIGEN IN ... Read more

Galectin-3, a beta-galactoside-binding animal lectin, is a multifunctionalprotein. Previous studies have suggested that galectin-3 may play an importantrole in inflammatory responses. Non-alcoholic fatty liver disease (NAFLD) isincreasingly recognized as a liver condition that may progress to end-stage liverdisease and based on the known functions of galectin-3, it was hypothesized that galectin-3 might play a role in the development of NAFLD. ... Read more

JC virus (JCV), a ubiquitous polyoma virus that commonly infects humans, wasfirst identified as the etiologic agent for the fetal demyelinating disease,Progressive multifocal leukoencephalopathy. Recently, a number of reports havedocumented detection of JCV in samples derived from several types of neural aswell as non-neural human tumors. It has been suggested that oncogenicity of JCV depends on a T antigen having ... Read more

Multi-functional galecin-3 is found in the nucleus as well as in the cytoplasm. In order to clarify the role of galectin-3 in progression of lung tumors we here immunohistochemically investigated levels in 300 non-small cell lung cancers (NSCLCs), 164 adenocarcinomas (ACs) and 136 squamous cell carcinomas (SCCs), using a monoclonal antibody, Galectin-3 was found to be overexpressed in the nucleus ... Read more

PURPOSE: Galectin-3, a beta-galactoside-binding animal lectin is amultifunctional protein, which regulates cell growth, cell adhesion, cellproliferation, angiogenesis, and apoptosis, and in turn contributes totumorigenesis and metastasis. The aim of this study was to clarify the role orrelated mechanisms of galectin-3 in lung carcinogenesis. METHODS: Weadministrated 4-(methylnitrosamino)-1-(3-pyridyle)-1-butanone (NNK), a powerful chemical carcinogen into galectin-3 wild-type (gal3+/+) and galectin-3 knock-out (gal3-/-) CD1 ... Read more