Hassan Mohamed Hassan Ali Elalaf

Lecturer - Lecturer - Physiology Dept. - Faculty of Medicine

Faculty of medicine

Address: Egypt- Sohag - Sohag city - ZIP Code: 82519


Pharmacological Double Inhibition of Glycolysis in glioblastoma Multiforme Cells Maximizes Cancer Cell Killing: A Synergism between Citrate and 3-bromopyruvate
BACKGROUND: Glioblastoma multiform (GBM) tumors are the most aggressive and diffusely infiltrating brain tumors in human patients. Despite surgery, modern chemotherapy and anti-angiogenesis treatments, GBM tumors regrow rapidly and end patients’ lives in a relatively short time. GBM tumors aggressively invade and infiltrate adjacent normal brain tissues. GBM cells are driven by glycolysis (glucose oxidation to produce ATP and lactate ... Read more

2019 | Keywords DM, Erythropoietin, Hypog,
Possible effects of erythropoietin on diabetic rats
BACKGROUND: Blood glucose is controlled by a pancreatic hormone, insulin, so any altered functions of the pancreas are associated with disturbances in blood glucose level. Erythropoietin (EPO) is glycoprotein produced mainly by the kidney as a result of reduced intracellular oxygen. This study was designed to investigate the effect of EPO on blood glucose level in normal and streptozocin-induced diabetic ... Read more

2019 | Keywords Gliomas, 3-bromopyruvate,
Glioma Spheroid Cells (3D Tumor Models) Are Less Responsive to 3-Bromopyruvate than Cultured Cells: Lack of Tumors Eradication.
BACKGROUND : Gliomas and glioblastomas are space-occupying brain tumors with variable aggressive behaviour. Glioblastomas are the most lethal brain tumors and are not responsive to current chemotherapy and radiotherapy. To date, no satisfactory curative treatment exists. 3-bromopyruvate (3BP) is a promising chemotherapeutic that proved effective in treating gliomas and other malignancies in so many reported studies. 3BP is both an ... Read more

Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes
Somatic mutations in the isocitrate dehydrogenase (IDH)1/2 genes endow encoding proteins with neomorphic activity to produce the potential oncometabolite, 2-hydroxyglutarate (2-HG), which induces the hypermethylation of histones and DNA. The incidence of IDH1/2 mutations in cartilaginous tumors was previously shown to be the highest among various types of tumors, except for those in the central nervous system. Mutations have been ... Read more