Dr.ramykamal

Ramy Kamal Amin Sayed

Lecturer - Lecturer of Veterinary Anatomy and Embryology

Faculty of Veterinary Medicine

Address: Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Sohag University

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Publications Which contain the keyword: NLRP3 inflammasome


Lack of NLRP3 inflammasome activation reduces age-dependent sarcopenia and mitochondrial dysfunction, favoring the prophylactic effect of melatonin
To investigate the role of NLRP3 inflammasome in muscular aging, we evaluated here the morphological and functional markers of sarcopenia in the NLRP3-knockout mice, as well as the beneficial effect of melatonin supplementation. The gastrocnemius muscles of young (3 months), early-aged (12 months), and old-aged (24 months) NLRP3-knockout female mice were examined. Moreover, locomotor activity and apoptosis were assessed. The ... Read more

2018-10-14 18:19:52 Keywords Heart, melatonin, NF-κB, NLRP3 deficiency, NLRP3 inflammasome, Sepsis,
Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis
The NLRP3 inflammasome is involved in the innate immune response during inflammation. Moreover, melatonin blunts the NF-κB/ NLRP3 connection during sepsis. Thus, we compared the roles of the NLRP3 inflammasome and/or melatonin treatment in the septic response of wild-type and NLRP3−/− mice. Mouse myocardial tissue was used for this purpose. The nuclear turnover of NF-κB was enhanced during sepsis, with ... Read more

2018-10-14 17:44:34 Keywords NLRP3 inflammasome, Muscle fibers, Mitochondria, CSA,
NLRP3 inflammasome affects mitochondrial morphology in skeletal muscle of mice
NLRP3 inflammasome seems to affect negatively skeletal muscle and mitochondria morphology. NLRP3 is associated with mitochondrial dysfunction and damage after its activation by inflammatory signals. Finally, these changes may reflect loss of efficacy of the skeletal muscle strength. Read more