ahmedabudief

Dr. Ahmed Mohamed Abu-Dief

Assistant Professor - Assistant professor of Inorganic and Physical Chemistry

Faculty of science

Address: Behind hospital of Sohag University - Ali Ebn Abi Taleb Street

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Publications Which contain the keyword: Pancreatic cancer


2019-02-08 01:34:37 Keywords Sphingolipid, Ceramide, PSC 833, Pancreatic cancer, Acid ceramidase,
Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells.
PURPOSE Acid ceramidase (AC) occupies an important place in the control of cancer cell proliferation. We tested the influence of AC inhibition on the effects of PSC 833, a P-glycoprotein antagonist with potent ceramide-generating capacity, to determine whether AC could be a therapeutic target in pancreatic cancer. METHODS Ceramide metabolism was followed using 3H-palmitate, and molecular species were determined by ... Read more

Management of Pancreatic Cancers
ABSTRACT BACKGROUND: pancreatic cancer remains a major health problem, with conventional cancer treatments having little impact on disease course. Almost all patients who have pancreatic cancer develop metastases and die, the disease is difficult to diagnose in its early stages, and most patients have incurable disease by the time they present with symptoms. The overall 5-year survival rate for this ... Read more

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