mamdouh.fawzi

Mamdouh Fawzy Ahmed Mohamed

Lecturer - Lecturer of Pharmaceutical Chemistry, Head of Pharmaceutical Chemistry Department Lab and Co-ordinate of Clinical Pharmacy Program

Faculty of Pharmacy

Address: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt

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Publications Which contain the keyword: Molecular docking

Utilization of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinone as a cap moiety in design of novel histone deacetylase inhibitors

2019-11-25 07:53:38 Keywords Tetrahydrobenzo[4, 5]Thieno[2, 3, Histone deacetylase inhibitors, Molecular docking, Anti-proliferative, Apoptotic assay,
Utilization of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinone as a cap moiety in design of novel histone deacetylase inhibitors
A series of novel 5,6,7,8-Tetrahydro[1]benzothieno[2,3_-d_]pyrimidin-4(3_H_)-one derivatives bearing a hydroxamic acid, 2-aminoanilide and hydrazide moieties as zinc-binding group (ZBG) were designed, synthesized and evaluated for the HDAC inhibition activity and antiproliferative activity. Most of the tested compounds displayed strong to moderate HDAC inhibitory activity. Some of these compounds showed potent anti-proliferative activity against human HepG2, MCF-7 and HCT-116 cell lines. In ... Read more

Antibacterial and Urease Inhibitory activity of New Piperazinyl N-4 Functionalized Ciprofloxacin-oxadiazoles

2019-11-25 08:49:32 Keywords Molecular docking, Urease inhibitors, antibacterial, Oxadiazole, Ciprofloxacin,
Antibacterial and Urease Inhibitory activity of New Piperazinyl N-4 Functionalized Ciprofloxacin-oxadiazoles
This research includes design of new ciprofloxacin bearing oxadiazole at the N-4 piperazinyl for the purpose of having urease inhibitory activity as well as antibacterial activity. Hence, a group of new N-4 piperazinyl oxdiazole derivatives of ciprofloxacin was prepared and characterized using different spectroscopic and analytical techniques including 1H-NMR, 13C-NMR, MS and elemental analysis. Compounds 5b and 5c experienced moderate ... Read more

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