Cholesteatoma is a proliferative disease of the middle ear with bone resorption activity. Its pathogenesis remains controversial and has yet to be clarified. Cytokeratins represent a well-known epithelial proliferative and differentiation markers. In the current study, we investigated expression of a large set of cytokeratins in cholesteatoma matrix versus deep meatal skin tissues from the same patients. Methodology: An immunohistochemical ...
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