أ.د. خالد عبداللطيف محمد عمران

استاذ - عميد كلية التربية - جامعة سوهاج

كلية التربية

العنوان: جمهورية مصر العربية - محافظة سوهاج - جامعة سوهاج - كلية التربية



المنشورات و المؤلفات التي تحتوي علي الكلمة المفتاحية: 2

β-RA reduces DMQ/CoQ ratio and recues the encephalopathic phenotype in Coq9R239X mice
Coenzyme Q (CoQ) deficiency has been associated with primary defects in the CoQ biosynthetic pathway or to secondary events. In some cases, the exogenous CoQ supplementation has limited efficacy. In the Coq9R239X mouse model with fatal mitochondrial encephalopathy due to CoQ deficiency, we have tested the therapeutic potential of b-resorcylic acid (b-RA), a structural analog of the CoQ precursor 4-hydroxybenzoic ... إقراء المزيد

2019-12-10 00:21:16 الكلمات المفتاحية Benzylidene, cyanopyridine, cyclic ketone, 2, 3-cycloalkenopyridine, multi-component reaction,
An Efficient Synthesis of Benzylidene-2-alkoxy-4-aryl-2,3-cycloalkenopyridine-3-carbonitrile Derivatives
An efficient procedure for the synthesis of a novel class of benzylidene-2-alkoxy-4-aryl-6,7-dihydro-5H-cyclopenta[b]pyridine-, -5,6,7,8-tetrahydroquinoline and/or -6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine- 3-carbonitrile was introduced through the one-pot multicomponent reaction of cyclopentanone, cyclohexanone, and/or cycloheptanone with different aromatic aldehydes and malononitrile. The same products were also produced by classical route by the two-component reaction of dibenzylidine cyclopentanone, cyclohexanone, and/or cycloheptanone derivatives with malononitrile. The reactions were achieved ... إقراء المزيد

2020-03-15 21:15:14 الكلمات المفتاحية Amidoxime;, arylamide;, arylnitrile;, cyanamide;, optimization;, pyrimidine;, 1, 2, 4-oxadiazole,
Optimization of the synthesis of het/aryl-amidoximes using an efficient green chemistry
This work focuses on optimizing an efficient green synthesis of arylamidoximes from appropriate nitrile and hydroxylamine hydrochloride in water and triethylamine (1.6 mol equivalent) as a base at room temperature for 6 h. This new green synthetic methodology is compared with previously known methods. The main advantages of this new process reported are good yield, easier work-up and short reaction ... إقراء المزيد

2018-11-25 00:12:16 الكلمات المفتاحية suaeda maritima, callus, salt tolerance, superoxide dismutase, 2, 4-D_2.4-dichlorophenoxyaceti,
Differential tolerance to high salt with regard to cell growth and superoxide dismutase (SOD) activity in calluses of the halophyte Suaeda maritima from Japan and Egypt
To determine the mechanism of regulation of superoxide dismutase (SOD; EC isozymes in halophytes at the cellular level,we isolated calluses from Suaeda maritima plants native to Japan and Egypt. Calluses from Egyptian S. maritima could grow in a high salt medium (~400 mM NaCl), whereas Japanese S. maritima calluses could not. The expression characteristics of SOD isozyme genes encoding ... إقراء المزيد

2018-11-14 13:47:52 الكلمات المفتاحية 1, 2, 4-Triazole,
Synthesis and Antibacterial Activity of Some New 4-anilino-5-phenyl-4H-1,2,4-triazole-3-thiol derivatives
4-Anilino-5-phenyl-4H-1,2,4-triazole-3-thiol (1) reacted with formaldehyde and different amines to give Mannich bases 2a–i. Treatment of compound 1 with formaldehyde afforded the corresponding 2-hydroxymethyl derivative 3, which upon its reaction with thionyl chloride yielded the corresponding chloromethyl derivative 4. Treatment of compound 4 with some thiols gave the corresponding sulfides 5a–f. The ring closure reaction of chloromethyl derivative 4 with hydrazine ... إقراء المزيد

2018-10-30 09:28:34 الكلمات المفتاحية Ketene N, S-acetals, N-phenyl-2-ylidene, 2, 5-diylidene-4-thiazolidinone,
Ketene N,S-acetals in heterocyclic synthesis: Part 1: Synthesisof N-phenyl-2-ylidene and 2,5-diylidene-4-thiazolidinone derivatives"
Ketene N,S-acetals in heterocyclic synthesis: Part 1: Synthesisof N-phenyl-2-ylidene and 2,5-diylidene-4-thiazolidinone derivatives" إقراء المزيد

2018-10-30 09:47:43 الكلمات المفتاحية Substituted(1, 5)benzodiazepin, 1, 3-Oxazino, 1, 3-Oxazine, 1, 2, 4-Triazole,
A Novel Synthesis of Pyrano(2,3-c)-1,3-Oxazino(2,3-b)-1,2,4-Triazolo(3,4-b)- and 3-Substituted(1,5)benzodiazepin-2-one
A Novel Synthesis of Pyrano(2,3-c)-1,3-Oxazino(2,3-b)-1,2,4-Triazolo(3,4-b)- and 3-Substituted(1,5)benzodiazepin-2-one إقراء المزيد

2018-10-14 08:59:37 الكلمات المفتاحية 1-methyl-4-phenyl-1, 2, 3, 6- tet, mitochondrial complex, mitochondrial-related genes, parkinson’s disease, zebrafish,
Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network
Multiple studies reporting mitochondrial impairment in Parkinson’s disease (PD) involve knockout or knockdown models to inhibit the expression of mitochondrial-related genes, including parkin, PINK1, and DJ-1 ones. Melatonin has significant neuroprotective properties, which have been related to its ability to boost mitochondrial bioenergetics. The meaning and molecular targets of melatonin in PD are yet unclear. Zebrafish are an outstanding model ... إقراء المزيد

2018-09-24 11:03:45 الكلمات المفتاحية 4]triazole, 2, pyrazolyl-[1,
Synthesis of 3-Pyrazolyl-1,2,4-Triazoles via One-Pot Multicomponent Reaction in Phosphoric Acid
A high-yielding synthetic route towards pyrazolyl-[1,2,4]triazole derivatives has been developed via one-pot multicomponent reaction of polyfunctionalized triazoles, DMF-DMA, acetophenone, ethyl cyanoacetate, and/or 3-oxo-3-phenylpropanenitrile in _ortho_-phosphoric acid (85%). In the same manner, a new series of 2-triazolyl-tetrahydro-indazol-4-ones and pyrazolo[3,4-_d_]pyrimidines has been synthesized by reaction of triazoles, DMF-DMA and 1,3-cyclohexanediones and/or barbituric acid, respectively. The same products were prepared a classical manner ... إقراء المزيد

Synthesis of 2-(2-methyltetrazol-5-yl)-2,2-dinitroacetonitrile. Reaction of the nitrile group with diazomethane
The reaction of the silver salt of (2-methyltetrazol-5-yl)dinitromethane with cyanogen bromide led to the formation of 2-(2-methyltetrazol-5-yl)-2,2-dinitroacetonitrile. The nitrile group of the latter was capable of entering into 1,3-dipolar cycloaddition with diazomethane, giving a mixture of isomeric 2-methyl-5-[(_N_-methyl-1,2,3-triazol-4-yl)dinitromethyl]tetrazoles that were separated by column chromatography. Upon treatment with an alcohol solution of potassium hydroxide, denitration of the cycloaddition products occurred and ... إقراء المزيد