el.saghier

Ahmed M. El-Saghier

Professor - Chairman of Chemistry Department

Faculty of science

Address: Chemistry Department, Faculty of Science, Sohag University

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Publications Which contain the keyword: pyrimidine;

Optimization of the synthesis of het/aryl-amidoximes using an efficient green chemistry

2020-03-15 21:15:14 Keywords Amidoxime;, arylamide;, arylnitrile;, cyanamide;, optimization;, pyrimidine;, 1, 2, 4-oxadiazole,
Optimization of the synthesis of het/aryl-amidoximes using an efficient green chemistry
This work focuses on optimizing an efficient green synthesis of arylamidoximes from appropriate nitrile and hydroxylamine hydrochloride in water and triethylamine (1.6 mol equivalent) as a base at room temperature for 6 h. This new green synthetic methodology is compared with previously known methods. The main advantages of this new process reported are good yield, easier work-up and short reaction ... Read more

Synthesis of Some New F used P yridines and Prediction their Biological Activity via PASS INET

2018-10-31 16:47:41 Keywords PASS INET, fused pyridine, pyrrazole;, pyrimidine;, pyrrole, pyridine;, phase transfer catalysis,
Synthesis of Some New F used P yridines and Prediction their Biological Activity via PASS INET
A new series of fused heterocyclic compounds containing pyridine moieties were prepared via the reaction of 2-amino-6-(methylthio)-4-phenylpyridine-3,5-dicarbonitrile with some halo reagents, active methylenes, acetic anhydride, phenylisothiocyanate, hydrazine hydrate or thioacetamide. Accompanied with Predictions of the activity spectra of some selected compounds using PASS INET.at Pa > 70%, showing high probability of Atherosclerosis treatment, Antineoplastic, DNA intercalator, Protein kinase inhibitor and ... Read more

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