Liver cirrhosis represents a major health problem. No effective anti-fibrotic therapy is available up till now. Understanding the pathogenesis of liver fibrosis is essential for developing new strategies for anti- fibrotic therapies. Animal models may be used for this purpose [1,2]. Animal models have several advantages compared to clinical studies including; the possibility of taking samples at different time-points, the ... Read more

_The liver plays a major role in lipid metabolism, importing free fatty acids and manufacturing, storing, and exporting lipids; derangements in any of these processes can lead to the development of non-alcoholic fatty liver disease (NAFLD). Fatty acid synthase (FAS) is a key enzyme in de novo lipogenesis and circulating FAS is a biomarker of metabolically demanding human diseases. In ... Read more