ahmedabudief

Dr. Ahmed Mohammed Abu-Dief Mohammed

Assistant Professor - Assistant professor of Inorganic and Physical Chemistry

Faculty of science

Address: Behind hospital of Sohag University - Ali Ebn Abi Taleb Street

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Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety
INTRODUCTION: Histone deacetylases (HDACs) represent one of the most validated cancer targets. The inhibition of HDACs has been proven to be a successful strategy for the development of novel anticancer candidates. METHODS: This work describes design and synthesis of a new set of HDAC inhibitors ( 7A-C and 8A, B) utilizing ligustrazine as a novel cap moiety, and achieving the ... Read more

Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety
INTRODUCTION: Histone deacetylases (HDACs) represent one of the most validated cancer targets. The inhibition of HDACs has been proven to be a successful strategy for the development of novel anticancer candidates. METHODS: This work describes design and synthesis of a new set of HDAC inhibitors ( 7A-C and 8A, B) utilizing ligustrazine as a novel cap moiety, and achieving the ... Read more

Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety
INTRODUCTION: Histone deacetylases (HDACs) represent one of the most validated cancer targets. The inhibition of HDACs has been proven to be a successful strategy for the development of novel anticancer candidates. METHODS: This work describes design and synthesis of a new set of HDAC inhibitors ( 7A-C and 8A, B) utilizing ligustrazine as a novel cap moiety, and achieving the ... Read more

2019-12-29 22:00:57 Keywords carbon nanotubes, Sorafenib, ,
Accelerated Stability Testing of Microcapsulated Sorafenib-loaded Carbon nanotubes Prepared by emulsification/internal gelation Method
This work aims to evaluate the effect of environmental factors, including temperature, humidity, and light, on the quality of a drug substance or a formulated product which is utilized for prediction of its shelf life, to determine proper storage conditions and to suggest labeling instructions. Moreover, the data generated during the stability testing is an important requirement for regulatory approval ... Read more

2019-12-14 20:14:42 Keywords Mareks disease virus- EBERs, ,
Epstein-Barr virus-encoded RNAs (EBERs) complement the loss of Herpesvirus telomerase RNA (vTR) in virus-induced tumor formation
Marek’s disease virus (MDV) is an alphaherpesvirus that causes fatal lymphomas in chickens and is used as a natural virus-host model for herpesvirus-induced tumorigenesis. MDV encodes a telomerase RNA subunit (vTR) that is crucial for efficient MDV-induced lymphoma formation; however, the mechanism is not completely understood. Similarly, Epstein Barr-virus (EBV) encodes two RNAs (EBER-1 and EBER-2) that are highly expressed ... Read more

2019-12-04 13:09:08 Keywords Single Vein, Perforator Flap, ,
Safety of Single Vein Anastomosis versus Double Venous Anastomosis in ALT Perforator Flap in Foot and Leg Reconstruction
Introduction: Single or double venous anastomosis in free flap in general and ALT, in particular, is still a matter of debate between micro vascular surgeons. In this study, we will present our experience in single vein anastomosis versus double venous anastomosis in ALT perforator flap used in leg and foot reconstruction as regarding flap outcome, complications, operation time and the ... Read more

Closed-Chamber Anterior Capsulorhexis Under Air Tamponade In White Cataract
Purpose: To evaluate the efficacy and safety of a closed-chamber air bubble capsulotomy technique to prevent the Argentinean flag sign (AFS) in patients with white and intumescent cataracts. Setting: Sohag University, Faculty of Medicine, Ophthalmology Department, Sohag, Egypt. Design: Prospective interventional noncomparative case series. Methods: Eighty-two eyes of 80 patients with white and intumescent cataracts were included. Eyes with any ... Read more

Closed-Chamber Anterior Capsulorhexis Under Air Tamponade In White Cataract
Purpose: To evaluate the efficacy and safety of a closed-chamber air bubble capsulotomy technique to prevent the Argentinean flag sign (AFS) in patients with white and intumescent cataracts. Setting: Sohag University, Faculty of Medicine, Ophthalmology Department, Sohag, Egypt. Design: Prospective interventional noncomparative case series. Methods: Eighty-two eyes of 80 patients with white and intumescent cataracts were included. Eyes with any ... Read more

2019-10-04 04:46:42 Keywords UV-Irradiation, , TiO2, Energy Production,
Near UV-irradiation of CuOx-impregnated TiO2 providing active species for H2 production through methanol photoreforming
Copper doped‐TiO2 (P25) nanomaterials have been intensively studied as promising catalysts for H2 production by photo‐reforming of selected organic compounds. However, the role of copper oxidation states on the improvement of photocatalytic activity is still debated. In this work, CuOx‐impregnated P25‐TiO2 catalysts were used for photocatalytic production of hydrogen from methanol. Copper species/oxidation states both in the as‐prepared catalysts and ... Read more

β-RA reduces DMQ/CoQ ratio and recues the encephalopathic phenotype in Coq9R239X mice
Coenzyme Q (CoQ) deficiency has been associated with primary defects in the CoQ biosynthetic pathway or to secondary events. In some cases, the exogenous CoQ supplementation has limited efficacy. In the Coq9R239X mouse model with fatal mitochondrial encephalopathy due to CoQ deficiency, we have tested the therapeutic potential of b-resorcylic acid (b-RA), a structural analog of the CoQ precursor 4-hydroxybenzoic ... Read more