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Khalaf Ali Fayez Abuamra

استاذ - أستاذ متفرغ

كلية العلوم

العنوان: قسم النبات والميكروبيولوجى -كلية العلوم -جامعة سوهاج

3

إعجاب

المنشورات و المؤلفات التي تحتوي علي الكلمة المفتاحية: 4-oxadiazoles


2019-04-26 22:38:01 الكلمات المفتاحية Aryl carboximidamides1, 2, 4-o, Aryl carboximidamides, 1, 2, 4-oxadiazoles, COX-1, COX-2, 15- LOX, Naproxe, anti-inflammatory,
Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies
A series of novel naproxen analogues containing 3-aryl-1,2,4-oxadiazoles moiety (4B-G) and their reaction intermediates aryl carboximidamides moiety (3B-G) was synthesized and evaluated _in vitro_ as dual COXs/15-LOX inhibitors. Compounds 3B-G exhibited superior inhibitory activity than celecoxib as COX-2 inhibitors. Compounds 3B-D and 3G were the most potent COX-2 inhibitors with IC50 range of 6.4 – 8.13 nM and higher selectivity ... إقراء المزيد

2019-12-10 00:08:59 الكلمات المفتاحية Aryl carboximidamides 1, 2, 4-, Aryl carboximidamides, 1, 2, 4-oxadiazoles, COX-1, COX-2, 15- LOX, Naproxen, anti-inflammatory,
3.	Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies
A series of novel naproxen analogues containing 3-aryl-1,2,4-oxadiazoles moiety (4b-g) and their reaction intermediates aryl carboximidamides moiety (3b-g) was synthesized and evaluated in vitro as dual COXs/15-LOX inhibitors. Compounds 3b-g exhibited superior inhibitory activity than celecoxib as COX-2 inhibitors. Compounds 3b-d and 3g were the most potent COX-2 inhibitors with IC50 range of 6.4 – 8.13 nM and higher selectivity ... إقراء المزيد

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