ghada_galal

Ghada Galal

Professor - Head of Tropical Medicine and Gastroenterology Department

Faculty of medicine

Address: Sohag, Egypt

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Publications Which contain the keyword: Apoptosis


2019-02-08 01:05:20 Keywords Triterpenoids Oleanolic acid , , Mitocan, prostate cancer, ROS, Apoptosis,
Oleanolic acid methyl ester, a novel cytotoxic mitocan, induces cell cycle arrest and ROS-Mediated cell death in castration-resistant prostate cancer PC-3 cells
Oleanolic acid derivatives exhibit potent anticancer activities against numerous types of cancer. However, the antitumor activity of oleanolic acid methylester (OAME), an oleanolic acid derivative, against prostate cancer has not been studied. Hence, the present work was conducted to study the anticancer activities of OAME. Viability assay showed that treatment of cancer cells with OAME induced a significant cell death ... Read more

2018-10-23 00:01:11 Keywords Psoriasis, Apoptosis, calcipotriol, mometasone furoate,
Comparative study between the effect of calcipotriol and combination of calcipotriol and mometasone furoate on apoptosis in psoriatic patients.
OBJECTIVES: To compare the expression of Bcl-xl (antiapoptotic) and Bax (proapoptotic) factors in psoriatic patients treated with calcipotriol alone with those treated with combination of calcipotriol and mometasone furoate, also to compare the expression of these factors in keratinocytes of lesional with non lesional skin of psoriatic patients and of controls, and lastly to correlate the level of these parameters ... Read more

2018-10-14 19:02:29 Keywords Aging, Apoptosis, autophagosome, melatonin, gastrocnemius, Sarcopenia,
The protective effect of melatonin against age-associated sarcopenia-dependent tubular aggregates formation, lactate depletion and mitochondrial changes
To gain insight into the mechanism of sarcopenia and the protective effect of melatonin, the gastrocnemius muscles of young (3-4 months), early-aged (12 months), and old-aged (24 months) wild type C57BL/6J female mice, were examined by magnetic resonance and microscopy. Locomotor activity, lactate production and nuclear apoptosis were also assessed. The results support the early onset of sarcopenia at 12 ... Read more

2018-10-16 08:05:22 Keywords testes, electr, testes, mobile phone, Apoptosis, proliferation,
Effect of mobile phone radiation on proliferation and apoptosis in rabbit testes: a histological and immunohistochemical study
Introduction New technologies such as mobile phones can cause health problems. Electromagnetic radiation increases oxidative stress and apoptosis in some tissue cells. Testes are claimed to be one of these tissues. Aim of the work This work was carried out to evaluate the effects of mobile phone usage on proliferation and apoptosis in testicular tissue, and the probable role of ... Read more

Histological and immunohistochemical effects of the ink fluid of the sea hare Aplysia dactylomela on splenic macrophages of mice
Sea hares, _Aplysia dactylomela_, are soft bodied Opisthobranch mollusks which inhabit the shallow water of the Red sea. They release purple and sticky ink secretion towards the attacker to defend themselves. Sea hares caused many cases of human toxicity especially in people of some Asian countries who used to feed on it as in Japan, China, Philippines and Fiji. The ... Read more

Ultrastructural study on the effect of ink fluid of the sea hare Aplysia dactylomela on mice hepatocytes and kidney tubules of male mice.
SEA HARES ARE A GROUP OF MARINE MOLLUSCS WHICH POSSESS MANY WAYS FOR DEFENSE INCLUDING THE CHEMICAL DEFENSE. THE HARES PRODUCE INK FLUID FROM THE INK GLAND TO ESCAPE AND PROTECT THEMSELVES FROM THEIR ENEMIES. THE INK GLAND OF SEA HARES SECRETE, THE INK FLUID WHICH CONTAINS MANY BIOACTIVE FACTORS ACTING AGAINST POTENTIAL ENEMIES WITH TOXIC ACTIVITIES. _APLYSIA DACTYLOMELA_ IS ... Read more

2018-09-27 23:29:28 Keywords Apoptosis, α-SMA, fibrosis, , Apoptosis, α-SMA, cirrhosis,
Impact of omega-3 fatty acids on evolution of carbon tetrachloride- (CCl4) induced liver cirrhosis in mice : A histological and immunohistochemical study.
Introduction: Cirrhosis is the end stage of any chronic liver disease. It is characterized by diffuse fibrosis with disturbed hepatic architecture. Omega-3 polyunsaturated fatty acids are common antioxidant, anti-inflammatory and anti-fibrotic agents Aim: This study was conducted to investigate the potential effects of omega-3 fatty acids on experimentally induced cirrhosis. Materials and Methods: 60 animals were divided into three groups: ... Read more

2018-09-27 23:29:28 Keywords Apoptosis, α-SMA, fibrosis, , Apoptosis, α-SMA, cirrhosis,
Impact of omega-3 fatty acids on evolution of carbon tetrachloride- (CCl4) induced liver cirrhosis in mice : A histological and immunohistochemical study.
Introduction: Cirrhosis is the end stage of any chronic liver disease. It is characterized by diffuse fibrosis with disturbed hepatic architecture. Omega-3 polyunsaturated fatty acids are common antioxidant, anti-inflammatory and anti-fibrotic agents Aim: This study was conducted to investigate the potential effects of omega-3 fatty acids on experimentally induced cirrhosis. Materials and Methods: 60 animals were divided into three groups: ... Read more

2018-09-12 22:46:15 Keywords P53, breast cancer, Apoptosis,
Immunohistochemical p53 expression in breast carcinoma with correlation to clinic-pathological parameters.
Background: P53 is a tomour suppressor gene that plays a critical role in preventing human cancer formation. In response to a variety of of stress signals p53 becomes activated and induces cell cycle arrest and/or apoptosis. We Aimed to: 1. study the immunohistochemical profileof p53 in breast carcinoma (BC). 2. Assess its prognostic value in relation to clinico-pathological prognostic factors ... Read more

2018-09-06 09:20:17 Keywords Apoptosis, Breast Carcinoma, Bax, Bcl-xl,
Studying of Apoptosis in Breast Carcinoma; Immunohistochemical Evaluation of Pro- and Anti-apoptotic Gene Products Bax and Bcl-xl
Cancer cells acquire their hallmarks of malignancy through the accumulation of gene activation and inactivation over long periods of time. Gene expression studies offer the greatest promise for refining prognostication in breast cancer. For breast cancer, this multistep process may manifest itself as a sequence of pathologically defined stages. Dys-regulation of apoptosis overrides many of the normal checkpoint pathways and ... Read more