amr_ali

Amr Abdelhamed Ali Yousef

Lecturer - Lecturer, Department of Dermatology, Venereology & Andrology

Faculty of medicine

Address: Faculty of Medicine, Sohag University.

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Publications Which contain the keyword: P53


2019-02-08 01:08:26 Keywords Colorectal cancer, Ceramide, P53, tamoxifen, P-glycoprotein,
Tamoxifen magnifies therapeutic impact of ceramide in human colorectal cancer cells independent of p53.
Poor prognosis in patients with later stage colorectal cancer (CRC) necessitates the search for new treatment strategies. Ceramide, because of its role in orchestrating death cascades in cancer cells, is a versatile alternative. Ceramide can be generated by exposure to chemotherapy or ionizing radiation, or it can be administered in the form of short-chain analogs (C6-ceramide). Because intracellular P-glycoprotein (P-gp) ... Read more

2018-10-22 21:36:49 Keywords Carcinoma, adenoma, Colorectal, ApopTag, Ki-67., P53, Bax, Bcl-2,
Immunohistochemical Study, In Situ Hybridization and Computerized Image Analysis of Colorectal Epithelial Progression from Adenoma to Carcinoma
SUMMARY: Adenoma-carcinoma sequence was postulated for most colorectal carcinomas. Deregulation of apoptosis and cellular proliferation is involved in the pathogenesis of neoplasia. The apoptotic genes that have been characterized in colon cancer are bcl-2, bax, and p53. Studying the expression of these genes and of the proliferating cell marker (Ki-67) in adenoma carcinoma sequence well be of great value in ... Read more

2018-10-22 22:17:49 Keywords Carcinoma, Colorectal, ApopTag, Ki-67, P53, Bax, Bcl-2,
Apoptosis and Colorectal Carcinoma; a Multiparameter Immunohistochemical, and Computerized Image Analysis Study
ABSTRACT: The last few years showed an increase in the incidence of the colorectal cancer in Egypt. Between 20% and 50% of patients with this cancer are susceptible to death within five years of diagnosis. Tumor growth results from a disturbance in the balance between the rates of cell proliferation and cell death (apoptosis). We studied the expressions of proteins ... Read more

2018-10-16 15:17:40 Keywords Bcl-2, Bax, P53, STAT3, β-Catenin, COLON, adenoma, Carcinoma,
Comparative study of Bcl-2, Bax, p53, STAT3 and β-catenin and their relationship to colonic epithelial progression from adenomas to carcinomas: a multiparameter immunohistochemical computerized image analysis study
ABSTRACT: Adenoma-carcinoma sequence was postulated for most colorectal carcinomas. Deregulation of apoptosis & cell proliferation is involved in the pathogenesis of neoplasia. The apoptosis genes characterized in colon cancer are bcl-2, bax & p53. b-catenin plays a role in both cell adhesion & intracellular signaling. Translocation of b-catenin from the cell membrane to the cytoplasm or nucleus is an early ... Read more

2018-10-01 10:26:39 Keywords H . Pylori, chronic gastritis, P53,
Immunohistochemical Detection of P53 in Helicobacter Pylori Gastritis
Abstract: Aim of the work: This study was designed to detect mutation in P53 in cases of non-neoplastic Helicobacter Pylori (H. Pylori) gastritis. Method: 55 cases of chronic H. Pylori gastritis were selected and we used immunohistochemical technique to detect P53 expression and compared it with the five parameters in Sydney system (gastric atrophy, intestinal metaplasia, chronicity, and activity and ... Read more

2018-09-26 09:31:11 Keywords DCIS, IDC, Ki67, P53,
PROLIFERATIVE INDEX AND P53 EXPRESSION IN BREAST CARCINOMA AND THEIR CORRELATION TO CLINICO-PATHOLOGICAL PARAMETERS
BACKGROUND: Breast cancer is the most frequently diagnosed cancer and the most common cause of cancer deaths in women worldwide. Ki67 is a biomarker that reflects cell proliferation. Despite a clear understanding of the structure and properties of this protein, its functional role remains elusive. Gene expression alteration confers the potential for invasive growth in the preinvasive stages of breast ... Read more

2018-09-16 11:55:48 Keywords hepatoblastoma, P53, EGF,
Expression of C-KIT Tyrosine Kinase Receptor, Epidermal Growth Factor, and p53 Proteins in the epithelial and mesenchymal cells of Hepatoblastoma: Preli.minary Findings
Background: Overexpression of receptor-type protein tyrosine kinases (PTKs) and alterations of p53 are well known events in neoplastic cells and are associated with an aggressive tumor phenotype. To date, our knowledge about PTKs and p53 expression in the neoplastic cells (epithelial and mesenchymal cells) of hepatoblastoma is incomplete. Objectives: This study tries to address this issue and test the hypothesis ... Read more

2018-09-12 15:34:13 Keywords o breast, DCIS, Bcl-xl, Bax, Bcl-2, P53,
Expression of p53, bcl-2, bax and bcl-xl in ductal carcinoma in situ (DCIS) of the breast.
BACKGROUND: DCIS is a malignant proliferation of mammary ductal epithelial cells without invasion beyond the basement membrane. Bcl-2, bax, bcl-xl and p53 are implicated in regulation of apoptosis. This study aimed to clarify the role of these gene products in DCIC. MATERIALS AND METHODS: Immunohistochemical staining of 13 cases of DCIS with bcl-2, bax, bcl-xl and p53 was performed. RESULTS: ... Read more

2018-09-12 22:46:15 Keywords P53, breast cancer, Apoptosis,
Immunohistochemical p53 expression in breast carcinoma with correlation to clinic-pathological parameters.
Background: P53 is a tomour suppressor gene that plays a critical role in preventing human cancer formation. In response to a variety of of stress signals p53 becomes activated and induces cell cycle arrest and/or apoptosis. We Aimed to: 1. study the immunohistochemical profileof p53 in breast carcinoma (BC). 2. Assess its prognostic value in relation to clinico-pathological prognostic factors ... Read more

2018-09-15 15:40:09 Keywords P53, Helicobacter Pylori, chronic gastritis,
Immunohistochemical Detection of P53 in Helicobacter Pylori Gastritis
Abstract: Aim of the work: This study was designed to detect mutation in P53 in cases of non-neoplastic Helicobacter Pylori (H. Pylori) gastritis. Method: 55 cases of chronic H. Pylori gastritis were selected and we used immunohistochemical technique to detect P53 expression and compared it with the five parameters in Sydney system (gastric atrophy, intestinal metaplasia, chronicity, and activity and ... Read more