2.	A regioselective and convenient one-pot multicomponent synthesis of polyfunctionalized 4-aryl-2-cyanoimino-3,4-dihydro-1H-pyrido[2,3-d]pyrimidines
A novel series of 5,7-diamino-4-aryl-6-cyano-2-cyanoimino-3,4-dihydro-1H-pyrido[2,3-d]pyrimidines (aryl-CIDHPPMs) 3a–i was prepared via the one-pot four-component reaction of cyanoguanidine with aromatic aldehydes and malononitrile with molar ratio (1:1:2) using sodium methoxide as catalyst. These new polyfunctionlized aryl-CIDHPPMs were also synthesized by a classical route via reaction of cyanoguanidine with the respective arylidenes of malononitrile dimer under the same condition. In the same manner, ... Read more