wael_gamaleldin

wael_gamaleldin

Assistant Professor - professor

Faculty of medicine

Address: sohag university hospital - urology dept

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Publications Which contain the keyword: Breast Carcinoma


2020-09-05 20:24:15 Keywords E-cadherin, Breast Carcinoma,
Immunohistochemical Expression of E-cadherin in Invasive Duct Carcinoma of the Breast.
Breast cancer is the most frequent malignant tumor in women worldwide. E-Cadherin is a calcium-dependent epithelial cell adhesion molecule that is expressed at adherens junctions. Its loss may result in a poorly differentiated tumorphenotype. Cells with mutated E-cadherin demonstrate increased motility,altered organization of their actin cytoskeletonandassociated with metastases, thereby providing evidence for its role as an invasion suppressor. Objectives:Assess the ... Read more

2018-10-01 10:15:51 Keywords TTF3, Breast Carcinoma,
Expression of the trefoil protein TFF3 in human breast cancers
The purpose of this study is to investigate expression of the trefoil factor family protein, TFF3 in a large series of human breast cancers. Trefoil factors are small secreted proteins that are expressed in mucus secreting epithelia. They are involved in mucosal protection in part by stimulation of cell motility. It has been proposed that the motogenic actions of trefoil ... Read more

2018-09-06 09:17:46 Keywords Breast Carcinoma, Bax, Bcl-2,
Evaluation of Immunohistochemical Anti-apoptotic Bcl-2 and Pro-apoptotic Bax Gene Products in Breast Carcinoma
One of the greatest challenges in breast cancer management is to accurately predict the outcome for each patient. To do this at present, we rely heavily on traditional pathological variables, such as tumor size, tumor grade and lymph node status. However, despite the broad applicability of clinico-pathological indices, they are still unable, to separate the 30% node-negative patients who will ... Read more

2018-09-06 09:20:17 Keywords Apoptosis, Breast Carcinoma, Bax, Bcl-xl,
Studying of Apoptosis in Breast Carcinoma; Immunohistochemical Evaluation of Pro- and Anti-apoptotic Gene Products Bax and Bcl-xl
Cancer cells acquire their hallmarks of malignancy through the accumulation of gene activation and inactivation over long periods of time. Gene expression studies offer the greatest promise for refining prognostication in breast cancer. For breast cancer, this multistep process may manifest itself as a sequence of pathologically defined stages. Dys-regulation of apoptosis overrides many of the normal checkpoint pathways and ... Read more

2018-09-06 09:22:28 Keywords P53, Breast Carcinoma, Clinico-pathological Parameters,
Immunohistochemical P53 Expression in Breast Carcinoma with Correlation to Clinico-Pathological Parameters
Breast cancer has emerged as a grave danger in the last 50 years. It represented 35.1% of total cancer in women in Egypt National Cancer Institute (NCI) series. Changes in cell loss factor could have a major impact on tumor growth or regression. A large percentage of cell loss from tumors was due to apoptosis. P53 is a tumor suppressor ... Read more

2018-09-06 09:26:34 Keywords Clinico-pathological Parameters, Breast Carcinoma, P53, COX-2,
Immunohistochemical Cyclooxygenase-2 (COX-2) and P53 expression in Breast Carcinoma with Correlation to Clinico-pathological Parameters
BACKGROUND/AIMS: Breast cancer is the most common cancer in Egyptian women. This study aims to: 1. Evaluate COX-2 and p53 expressions in the successive steps of breast carcinogenesis. 2. Determine the correlation between COX-2 and p53 with the clinico-pathological parameters in ductal breast carcinoma. PATIENTS AND METHODS: This study included 74 specimens of breast lesions. Data about patient’s age, tumor ... Read more

2018-09-06 09:29:23 Keywords COX-2, CD31, Breast Carcinoma, Clinico-pathological Parameters,
Immunohistochemical Cyclooxygenase-2 (COX-2) and CD31 Expression in Breast Carcinoma with Correlation to Clinico-pathological Parameters
BACKGROUND: Breast cancer is the most common cancer in Egyptian women. COX-2 seems to be involved in malignant transformation and tumor progression by affecting cell proliferation, mitosis, cell adhesion, apoptosis, immune surveillance, and angiogenesis. Angiogenesis is an important key step in tumor progression. Microvascular density (MVD), a surrogate marker of angiogenesis can be assessed by CD31 staining. AIMS This study ... Read more

2018-09-07 10:14:51 Keywords P53, Expression, Breast Carcinoma,
Evaluation of the Proliferation Index and p53 Protein Expression in Preinvasive and Invasive Breast Carcinoma
BACKGROUND: Breast cancer is the most frequently diagnosed cancer and the most common cause of cancer deaths in women worldwide. Ki67 is a biomarker that reflects cell proliferation. Despite a clear understanding of the structure and properties of this protein, its functional role remains elusive. Gene expression alteration confers the potential for invasive growth in the preinvasive stages of breast ... Read more

2018-09-07 10:16:37 Keywords Breast Carcinoma, Clinico-pathological, MVD,
Correlation of Microvessel density (MVD) and Proliferation Index (PI) with Clinico-pathological Parameters in Breast Carcinoma
BACKGROUND: One of the greatest challenges in breast cancer management is to accurately predict the outcome for each patient. Microvessel density (MVD) correlated closely with increasing number of tumor cells shed into the bloodstream and development of metastasis. Because proliferation status closely correlates with tumor aggressiveness, proliferation index (PI) is considered as an established prognostic marker for various tumors. WE ... Read more

Correlation of Breast Cancer Subtypes Based on ER, PR and HER2 Expression with Axillary Lymph Node Status
ABSTRACT BACKGROUND:Lymph node metastasis is the most important prognostic factor in breast cancer patients. The present study was carried out to evaluate the association between ER, PR and HER-2/neu expression status, separately and in combinations with axillary lymph node involvement. PATIENTS AND METHODS: Two hundred and fifty eight breast cancer patients treated with modified radical mastectomy with axillary lymph node ... Read more