Mohamed.abdelwahab

Mohamed Abdulwahab Mohamed Ali

Teadching-Assistant - عضو بعثة الاشراف المشترك بجامعة مايو كلينك بالولايات المتحدة الامريكية

Faculty of medicine

Address: قنا شارع عطا بلبص

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Publications Which contain the keyword: Hepatocellular carcinoma


Design And Characterisation Of Novel Sorafenib-Loaded Carbon Nanotubes With Distinct Tumour-Suppressive Activity InHepatocellular Carcinoma
PURPOSE Over the past 30 years, no consistent survival benefits have been recorded for anticancer agents of advanced hepatocellular carcinoma (HCC), except for the multikinase inhibitor sorafenib (Nexavar®), which clinically achieves only ~3 months overall survival benefit. This modest benefit is attributed to limited aqueous solubility, slow dissolution rate and, consequently, limited absorption from the gastrointestinal tract. Thus, novel formulation ... Read more

2018-11-21 05:50:57 Keywords patients outcomes, ablation, Hepatocellular carcinoma,
Determinants of Patients’ Outcomes Following Loco-regional ablation of Hepatocellular Carcinoma
:Background Hepatocellular carcinoma is the 2nd most common cause of cancer-related deaths worldwide with steadily increasing morbidity and mortality. Loco-regional ablative therapies are potentially curative treatment options for the early disease stages and they can be used as a bridge to liver transplantation The purpose of our study is to assess the clinical, laboratory and radiological factors that may affect ... Read more

2018-10-29 14:17:21 Keywords ANX, Hepatocellular carcinoma,
Annexin A2 expression and phosphorylation are upregulated and in hepatocellular carcinoma
Annexins (ANXs) constitute a family of Ca2+- dependent membrane-binding proteins; at least 20 of them have been described to date. Among these, Annexin A2 (ANXA2) has been revealed as a multi-functional protein in vitro. Its actual role in vivo, however, requires further investigation. We already reported that ANX-I (ANXA1) was up-regulated in hepatocellular carcinoma (HCC). The role of ANXA2 in ... Read more

2018-10-29 15:10:24 Keywords Hepatocellular carcinoma, perc,
Comparative study of the effects of percutaneous ethanol injection and radiofrequency ablation in cases treated with a straight or expandable electrode
Radiofrequency ablation (RFA) has become mainstream among non-surgical treatment modalities in clinical settings for the treatment of hepatocellular carcinoma. We have previously described the novel combination therapy of percutaneous ethanol injection and RFA (PEI-RFA) and reported that this combination therapy was more effective than RFA alone in terms of the induced volume of coagulated necrosis and the energy requirement for ... Read more

2018-10-29 00:51:31 Keywords Annexin A2, phosphorylation, Hepatocellular carcinoma,
Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma
Annexins (ANXs) constitute a family of Ca2+-dependent membrane-binding proteins; at least 20 of them have been described to date. Among these, Annexin A2 (ANXA2) has been revealed as a multi-functional protein in vitro. Its actual role in vivo, however, requires further investigation. We already reported that ANX-I (ANXA1) was up-regulated in hepatocellular carcinoma (HCC). The role of ANXA2 in various ... Read more

2018-09-21 07:57:32 Keywords Hepatocellular carcinoma, cirrh,
RISK FACTORS OF HEPATOCELLULAR CARCINOMA: ARE THEY THE SAME AMONG CIRRHOTIC AND NONCIRRHOTIC PATIENTS IN UPPER EGYPT?
Background: Hepatocellular carcinoma (HCC) is the commonest primary cancer of liver. Epidemiologic research exploring risk factors of HCC is important because of increasing frequency of the disease in Egypt with remarkable rise in noncirrhotic patientsIdentifying risk factors of HCC may help in decreasing its incidence. Aim: This study was carried out to identify risk factors of HCC among both cirrhotic ... Read more

Stemness-related transcriptional factors and homing gene expression profiles in hepatic differentiation and cancer
Stem cell transcriptional signature activation is an essential event in the development of cancer. This study aimed to investigate the differential expression profile of three pluripotency-associated genes (_OCT4_, _NANOG_, and _SOX2_), G-protein-coupled chemokine receptor 4 (_CXCR4_) and the ligand (_CXCL2_), and alpha feto-protein (_AFP_) in hepatogenic differentiated stem cells and in sera of hepatitis C virus (HCV) and HCV-induced hepatocellular ... Read more

Serum angiopoietin-2 as a tumor marker for Hepatocellular Carcinoma
ABSTRACT: BACKGROUND: THE PROCESS OF HEPATIC CARCINOGENESIS INVOLVES A PROGRESSION INCLUDING LARGE REGENERATIVE NODULES, TO DYSPLASTIC NODULES, AND FINALLY TO HEPATOCELLULAR CARCINOMA (HCC). HOWEVER, SOMETIMES DIFFERENTIATION OF HEPATOCELLULAR NODULES CAN BE DIFFICULT. ANGIOGENESIS IS FUNDAMENTAL TO THE DEVELOPMENT OF MALIGNANT TUMORS. THE AIM OF THIS STUDY WAS TO EVALUATE ANGIOGENESIS BY EVALUATION OF SERUM LEVEL OF ANGIOPOIETIN-2 IN PATIENTS WITH ... Read more

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