Dual A1/A2B Receptor Blockade Improves Cardiac and Renal Outcomes in a Rat Model of Heart Failure with Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is prevalent and often accompanied by the metabolic syndrome. Current treatment options are limited. Here we test the hypothesis that combined A1/A2B adenosine receptor blockade is beneficial in obese ZSF1 rats, an animal model of HFpEF with the metabolic syndrome. BG9928, a combined A1/A2B receptor antagonist, was administered orally (10 mg/kg/day) to obese ... Read more