ahmedabudief

Dr. Ahmed Mohammed Abu-Dief Mohammed

Assistant Professor - Assistant professor of Inorganic and Physical Chemistry

Faculty of science

Address: Behind hospital of Sohag University - Ali Ebn Abi Taleb Street

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Publications Which contain the keyword: DNA interaction


Reactivity Trends and Kinetic Inspection of Hydroxide Ion Attack and DNA Interaction on Some Pharmacologically Active Agents of Fe(II)  Complexes at Different Temperatures
The reactivity of few novel high‐spin Fe(II) complexes of Schiff base ligands derived from 2‐hydroxynaphthaldehyde and some variety of amino acids with the OH− ion has been examined in an aqueous mixture at the temperature range from 10 to 40°C. Based on the kinetic investigations, the rate law and a plausible mechanism were proposed and discussed. The general rate equation ... Read more

Kinetic study of the hydroxide ion attack on and DNA interaction with high spin iron(II) Schiff base amino acid chelates baering ONO donors
Kinetic study of some novel high spin Fe(II) complexes of Schiff base ligands derived from 5-bromsalicyaldehyde and amino acids with the OH− ion and DNA has been carried out. Based on the kinetic data, the rate law and a plausible mechanism were proposed. Kinetic data of the base catalyzed hydrolysis imply pseudo first-order double stage process due to the presence ... Read more

Physicochemichal properties, DNA interaction, antiviral and antioxidant activities of some Amino Acid Imine Chelates
Schiff base amino acid ligands which derived from the condensation of 3-methoxysalicylaldehyde (MS) or 4-diethylaminosalicylaldehyde (DS) with some of α-amino acids (Phenylalanine (Phe), Histidine (His), Tryptophan (Trp)) were prepared. Moreover, eleven Schiff base amino acid binary Fe(II) and Cu(II) complexes were prepared. In addition to, five ternary Cu(II) complexes which derived from the prepared Schiff base amino acid ligands as ... Read more

Some new nano-sized Fe(II), Cd(II) and Zn(II) Schiff base complexes : Sonochemical synthesis, characterization, DNA interaction, in vitro antimicrobial and anticancer activities
The complexes of Fe(II), Cd(II) and Zn(II) with Schiff base derived from 2-amino-3-hydroxypyridine and 3-methoxysalicylaldehyde have been prepared. Melting points, decomposition temperatures, Elemental analyses, TGA, conductance measurements, infrared (IR) and UV–Visible spectrophotometric studies were utilized in characterizing the compounds. The UV–Visible spectrophotometric analysis revealed 1:1 (metal-ligand) stoichiometry for the three complexes. In addition to, the prepared complexes have been used ... Read more

Sonochemical synthesis, DNA binding, antimicrobial evaluation and in vitro anticancer activity of nano-sized Cu(II), Co(II) and Ni(II) chelates  as precursors for metal oxides
Three new nano sized Cu(II), Co(II) and Ni(II) complexes of imine ligand derived from the condensation of 2-amino-3-hydroxypyridine and 3-methoxysalicylaldehyde have been prepared and investigated using various chemical techniques such as NMR, elemental analysis, molar conductance, IR, electronic spectra, TGA and magnetic momentmeasurements. The obtained chemical analysis data showed that the synthesis of 1:1 (metal:ligand) ratio and octahedral geometry was ... Read more

Some new nano-sized Cr(III), Fe(II), Co(II), and Ni(II) complexes: Structural characterization, electrochemical, antioxidant, antimicrobial, antiviral assessment and DNA interaction
To estimate the biological preference of synthetic small drugs towards DNA target, new metal based chemotherapeutic agents of nano-sized Cr(III), Fe(II), Co(II) and Ni(II) Schiff base complexes having N,N,O donor system were synthesized and thoroughly characterized by physic-chemical techniques. The redox behavior of the Cr(III), Fe(II) and Co(II) complex was investigated by electrochemical method using cyclic voltammetry. IR results proven ... Read more

Design and Development of Some Novel Metal Anil Chelates for DNA Interaction  and Pharmaceutical Applications
Air and moisture stable coordination compounds of some first transition metals such as Cr (III), VO (II), Ni(II) and Mn(II) with newly designed tri- and tetra-dentate imine ligands (HNAP, HNPN and ESPN) were synthesized. Tridentate imine ligands (HNAP, ESAP) were synthesized by reacting 2-hydroxynapthaldehyde (HN) with 2-aminophenol (AP), whereas tetra-dentate imine ligands (HNPN and ESPN) were prepared by reacting 2-hydroxy-1-napthaldehyde ... Read more

Ni(II) and Cu(II) complexes : synthesis, spectroscopic characterization, theoretical calculations, DNA interaction and antimicrobial studies
A novel Schiff base, namely _Z_‐3‐((2‐((_E_)‐(2‐hydroxynaphthyl)methylene)amino)‐5‐nitrophenylimino)‐1,3‐dihydroindin‐2‐one, was synthesized from the condensation of 2‐hydroxy‐1‐naphthaldehyde and isatin with 4‐nitro‐_o_‐phenylenediamine. It was structurally characterized on the basis of 1H NMR, 13C NMR and infrared spectra and elemental analyses. In addition, Ni(II) and Cu(II) complexes of the Schiff base ligand were prepared. The nature of bonding and the stereochemistry of the investigated complexes were ... Read more

Synthesis, characterization, DFT calculations and biological studies of Mn(II), Fe(II), Co(II) and Cd(II) complexes based on a tetradentate ONNO donor Schiff base ligand
This study highlights synthesis and characterization of a tetradentate ONNO Schiff base ligand namely (1, 1′- (pyridine-2, 3-dimethyliminomethyl) naphthalene-2, 2′-diol) and hereafter denotes as “HNDAP″ and selected metal complexes including Mn(II), Fe(II), Co(II) and Cd(II) as a central metal. HNDAP was synthesized from 1:2 M ratio condensation of 2, 3-diaminopyridine and 2- hydroxy-1-naphthaldhyde, respectively. The stoichiometric ratios of the prepared ... Read more

Design and nonlinear optical properties (NLO) using DFT approach of new chelates for DNA interaction, antimicrobial, anticancer activities and molecular docking studies
In recent years, metals based antitumor complexes have played a vital role in chemotherapy. Therefore, in this study, some new imine Cr(III), VO(II) and Ni(II) complexes incorporating ESAP imine ligand (2-Ethoxy-6-((2-hydroxy-phenylimino)-methyl)-phenol were designed and synthesized. The investigated complexes were fully characterized by micro analysis, infrared, electronic spectra, thermal analysis(TGA), conductivity as well as magnetic susceptibility measurements. Moreover, the stability constants ... Read more