khalaf.ali

Khalaf Ali Fayez Abuamra

استاذ - أستاذ متفرغ

كلية العلوم

العنوان: قسم النبات والميكروبيولوجى -كلية العلوم -جامعة سوهاج

3

إعجاب

المنشورات و المؤلفات التي تحتوي علي الكلمة المفتاحية: DNA interaction


Fabrication, Spectroscopic Characterization, Calf thymus DNA Binding Investigation, Antioxidant and Anti-cancer Activities of Some Antibiotic Azomethine Cu(II), Pd(II), Zn(II) and Cr(III) Complexes
This study was conducted to prepare novel azomethine chelates of Cu(II), Pd(II), Zn(II) and Cr(III) with tri-dentate dianionic azomethine OVAP ligand 2-[(2-Hydroxy-phenylimino)-methyl]-6-methoxy-phenol. The prepared compounds were characterized with the help of elemental analyses, spectral (NMR, FT-IR, UV-vis, mass), conductivity, magnetic and thermal measurements. The spectroscopic data suggest that the parent azomethine ligand bind to the investigated metal ions through both ... إقراء المزيد

2019-08-09 10:54:55 الكلمات المفتاحية Imine complexes, DFT Calculations, Antimicrobial activity, DNA interaction, anticancer activity,
Novel Azomethine Pd(II) and VO(II)  Based Metallo-Pharmaceuticals as Anticancer, Antimicrobial and Antioxidant  agents:  Design, Structural inspection,  DFT investigation and DNA interaction
The new NO bi-dentate imine ligand namely (2-[(3-Nitro-benzylidene)-amino]-benzoic acid) (NBA) imine ligand (L) and their Pd(II) and VO(II) complexes have synthesized and characterized utilizing different physiochemical methods including elemental analyses, FT-IR, NMR, molar conductance and magnetic susceptibility measurements. The stability constant of these complexes has also determined. The studies of these complexes were found to have [M (L)] composition where ... إقراء المزيد

2019-10-19 14:22:17 الكلمات المفتاحية DNA interaction, Azomethine Chelates, Antimicrobial activity, Anticancer efficiency, ANTIOXIDANT,
A robust in vitro Anticancerc, Antioxidant and Antimicrobial Agents Based on New Metal-Azomethine Chelates Incorporating Ag(I),  VO(II)  and Pd(II) Cations: Probing the Aspects of DNA Interaction
A novel azomethine ligand (HNAP) [HNAP = 1-(Pyridin-3-yliminomethyl)-naphthalen-2-ol] and its Ag(I), Pd(II) and VO(II) chelates have been synthesized and structurally inspected using a wide range of spectroscopic and analytical tools, including infra-red (IR), ultraviolet-visible (UV-Vis) and 1H NMR spectroscopy techniques, CHN analysis, molar conductance, magnetic susceptibility, and thermogravimetric analysis. The molar conductance measurements reveal that the chelates are non-electrolytes. The ... إقراء المزيد

2019-10-24 21:57:24 الكلمات المفتاحية DFT calculation, Antimicrobial activity, DNA interaction, Aryl imidazole metal chelates,
Synthesis and Characterization of New Cr(III), Fe(III) and Cu(II) Complexes Incorporating Multi-Substituted Aryl Imidazole Ligand: Structural, DFT, DNA Binding, and Biological Implications
Designing new metal-based molecular antibiotics is an efficient approach to overcome the growing threat of antimicrobial resistance. In this paper, novel Cr(III), Fe(III) and Cu(II) complexes comprising substituted aryl imidazole ligand (MSEB), namely (2-(1-(2-hydroxyethyl)-4,5-diphenyl-1H-imidazole-2-yl)(4-bromophenol)) have been synthesized and characterized using infra-red (IR), ultraviolet-visible (UV-Vis) and 1H, 13C NMR spectroscopic techniques, together with elemental (CHN) and thermogravimetric analyses, molar conductance, and ... إقراء المزيد

2018-11-21 09:20:56 الكلمات المفتاحية DNA interaction, Schiff base, Transition Metal Complexes, IR, TGA, NMR, Antimicrobial activity, Electronic spectra,
Synthesis, characterization, DNA cleavage and antimicrobial activity of Schiff base transition metal complexes containing heterocyclic ligand
SOME NOVEL SCHIFF BASE METAL COMPLEXES OF CU(II), CO(II), NI(II) AND FE(II) DERIVED FROM 2-AMINO-3-HYDROXYPYRIDINE AND 4-NITROBENZALDEHYDE WERE SYNTHESIZED. THESE COMPOUNDS WERE CHARACTERIZED BY ELEMENTAL ANALYSIS, MOLAR CONDUCTANCE, MAGNETIC SUSCEPTIBILITY, THERMAL MEASUREMENTS, INFRARED AND ULTRAVIOLET–VISIBLE SPECTRA. THE SCHIFF BASE AND METAL COMPLEXES DISPLAYED GOOD ACTIVITY (AGAINST THE BACTERIA, _ESCHERICHIA COLI,__SERRATIA MARCESCENCE_AND_MICROCCUS LUTEUS_, AND THE FUNGI _ASPERGILLUS FLAVUS_, _GETRICHM CANDIDUM _AND ... إقراء المزيد

Design, Synthesis, anticancer activity and molecular docking studies on a series of VO(II), Cr (III), Mn(II) and Ni(II) Mononuclear Chelates incorporating Quaridentate imine ligand as antitubulin agents
The present study was conducted to synthesis of some new imine Cr(III), VO(II), Mn(II) and Ni(II) complexes derived from the condensation of 2-amino phenol with 2-hydroxynapthaldehyde were synthesized. The prepared HNPN imine ligand was analyzed by its melting point, IR, 1H NMR and 13C NMR spectroscopies. The investigated HNPN imine complexes were characterized by elemental analysis, FT IR, Uv-vis and ... إقراء المزيد

2018-11-22 14:16:13 الكلمات المفتاحية Antimicrobial activity, DNA interaction, Amino acids, Catalytic activity, Copper(II), TGA, IR,
Complexation of Schiff bases incorporating of Salicylaldehyde Derivatives and Amino Acids to Copper(II) as an effective strategy for antimicrobial activity improvement, DNA Interaction and catalytic activity
Five Cu(II) complexes are tridentate Schiff bases amino acids ligands derived from condensation 3–methoxysalicylaldehyde (MS) or 4-diethylaminosalicylaldehyde (DS) with α-amino acids (L-phenylalanine(P), L-histidine (H), DL-tryptophane (T)). All ligands are analyzed by 1HNMR and 13CNMR. The investigated complexes have been prepared and characterized by elemental analysis, infrared spectra, ultraviolet-visible and thermal analysis in dynamic air atmosphere (40ml / min) at a ... إقراء المزيد

2018-11-22 14:29:06 الكلمات المفتاحية Catalytic activity, Antimicrobial Activities, Tetradentate Ligands, DNA interaction, IR, NMR, TGA,
Approach to Synthesis, Characterization, Antimicrobial Activities and Catalytic Activity of Some Transition Metal Complexes Containing Biologically Active Asymmetrical Tetradentate Ligands.
AIR AND MOISTURE STABLE COORDINATION COMPOUNDS OF FIRST TRANSITION METALS SUCH AS CO(II), NI(II) AND CU(II) WITH NEWLY DESIGNED SCHIFF BASE (BSIPH) INCORPORATING 5-BROMOSALICYALDEHYDE WITH ISATIN AND 4-NITRO-O-PHENYLENE DIAMINE HAVE BEEN SYNTHESIZED TO ELUCIDATE THE STRUCTURE OF METAL COMPLEXES. THEY ARE CHARACTERIZED BY ELEMENTAL ANALYSES, INFRARED, 1HNMR, 13CNMR, THERMAL ANALYSIS, UV-VISIBLE, CONDUCTIVITY AND MAGNETIC SUSCEPTIBILITY MEASUREMENTS. THE RESULTS SUGGEST THAT ... إقراء المزيد

2018-11-25 17:26:51 الكلمات المفتاحية Synthesis, DNA interaction, DFT studies, Antimicrobial activity, IR, TGA, Imidazole Ligand,
Synthesis, Characterization and Biological Studies of Some new Cr(III), Fe(III) and Cu(II) Complexes based on Multi-Substituted  Aryl Imidazole ligand
New Cr (III), Fe (III) and Cu (II) complexes with MSBB (2‐(1‐butyl‐4,5 diphenyl‐1H‐imidazol‐2‐yl)(4-bromophenol) were synthesized. The multi-substituted aryl imidazole ligand (MSBB) and its complexes were characterized by using elemental and thermal analysis, molar conductivity, magnetic susceptibility, UV-Vis spectral data, IR, and NMR. The obtained data showed that prepared complexes were 1 :1 (metal : ligand) ratio, octahedral (Oh) for all ... إقراء المزيد

2018-11-26 08:20:45 الكلمات المفتاحية DNA interaction, Antimicrobial activity, anticancer activity, complexes, Schiff base, VO(II), Pd (II),
New palladium (II) and silver (I) Schiff base complexes Promising antibiotic and anticancer agents
Some new complexes derived from Ag (I) and Pd(II) metal ions and HNA imine ligand (L) _i.e. _(2-[(6-Allylidene-2-hydroxy-cyclohexa-1,3-dienylmethylene)-amino]-benzoic acid) have been synthesized and characterized by elemental analyses, molar conductance, magnetic susceptibility measurements, IR, NMR and electronic spectral studies. Moreover, the stability constants of the synthesized complexes were determined spectrophotometrically. On the basis of molar conductance and elemental analyses the complexes ... إقراء المزيد