laila.abdelrahman

Laila.abdelrahman

Professor - Chairman of Inorganic Chemistry Branch

Faculty of science

Address: Chemistry Department, Faculty of Science, Sohag University

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Publications Which contain the keyword: DNA interaction

Synthesis, Structural elucidation, DFT calculation, Biological studies and DNA Interaction of Some Aryl hydrazone Cr3+, Fe3+, and Cu2+ Chelates

2022-02-13 01:16:14 Keywords DNA interaction,
Synthesis, Structural elucidation, DFT calculation, Biological studies and DNA Interaction of Some Aryl hydrazone Cr3+, Fe3+, and Cu2+ Chelates
The current research focuses on the treatment of Cr(III), Fe(III) and Cu(II) metal ions with aryl hydrazone ligand named (E)-4-(((diphenylmethylene)hydrazono)methyl)benzene-1,3-diol (DPHB) to afford four novel solid complexes with high yields. Different characterization approaches, including infrared, UV-visible, and NMR spectroscopies, elemental analyses, and thermal gravimetric analysis (TGA), revealed that all mononuclear crystalline metal chelates with good thermal stability had a six-coordination ... Read more

Structural inspection for Novel Pd (II), VO (II), Zn (II) and Cr (III)-Azomethine metal chelates: DNA interaction, Biological Screening and theoretical treatments

2021-12-19 23:38:03 Keywords DNA interaction,
Structural inspection for Novel Pd (II), VO (II), Zn (II) and Cr (III)-Azomethine metal chelates: DNA interaction, Biological Screening and theoretical treatments
An alternative sequence of bioactive series, using novel Schiff base derivative (1-Quinolin-8-yliminomethyl-naphthalen-2-ol), was produced (HNQ). Elements analysis, molar conductivity, magnetic moment, IR, 1H NMR, UV-Vis, and TGA were used to define the chemical forms. As a result, an appropriate geometry has been proposed for each complex. The HNQ ligand functions as a tri-dentate _via_ NNO donors to the metal ions ... Read more

Optimization for synthesized quinoline-based Cr3+, VO2+, Zn2+ and Pd2+ complexes: DNA interaction, biological assay and in-silico treatments for verification

2021-12-12 23:58:23 Keywords DNA interaction, biological as,
Optimization for synthesized quinoline-based Cr3+, VO2+, Zn2+ and Pd2+ complexes: DNA interaction, biological assay and in-silico treatments for verification
A novel momonuclear metal chelates were derived from Zn(II), Pd(II), VO(II) and Cr(III) ions with azomethine (BSQ) [BSQ = 4-Bromo-2-(quinolin-8-yliminomethyl)-phenol] ligand. The prepared compounds were subjected to different analytical and spectroscopic techniques as, IR, 1H NMR, UV–Vis, molar conductivity, magnetic moment and thermogravimetric analysis (TGA) to elucidate their structures. Accordingly, the most fitted geometry has been suggested for each complex. ... Read more

Fabrication, Spectroscopic Characterization, Calf thymus DNA Binding Investigation, Antioxidant and Anti-cancer Activities of Some Antibiotic Azomethine Cu(II), Pd(II), Zn(II) and Cr(III) Complexes

2019-03-20 07:58:21 Keywords Azomethine, Pd (II), Cu(II) Complexes, DNA interaction, Antimicrobial activity, Antioxidant capacity, anticancer activity,
Fabrication, Spectroscopic Characterization, Calf thymus DNA Binding Investigation, Antioxidant and Anti-cancer Activities of Some Antibiotic Azomethine Cu(II), Pd(II), Zn(II) and Cr(III) Complexes
This study was conducted to prepare novel azomethine chelates of Cu(II), Pd(II), Zn(II) and Cr(III) with tri-dentate dianionic azomethine OVAP ligand 2-[(2-Hydroxy-phenylimino)-methyl]-6-methoxy-phenol. The prepared compounds were characterized with the help of elemental analyses, spectral (NMR, FT-IR, UV-vis, mass), conductivity, magnetic and thermal measurements. The spectroscopic data suggest that the parent azomethine ligand bind to the investigated metal ions through both ... Read more

Novel Azomethine Pd(II) and VO(II) Based Metallo-Pharmaceuticals as Anticancer, Antimicrobial and Antioxidant agents: Design, Structural inspection, DFT investigation and DNA interaction

2019-08-09 10:54:55 Keywords Imine complexes, DFT Calculations, Antimicrobial activity, DNA interaction, anticancer activity,
Novel Azomethine Pd(II) and VO(II) Based Metallo-Pharmaceuticals as Anticancer, Antimicrobial and Antioxidant agents: Design, Structural inspection, DFT investigation and DNA interaction
The new NO bi-dentate imine ligand namely (2-[(3-Nitro-benzylidene)-amino]-benzoic acid) (NBA) imine ligand (L) and their Pd(II) and VO(II) complexes have synthesized and characterized utilizing different physiochemical methods including elemental analyses, FT-IR, NMR, molar conductance and magnetic susceptibility measurements. The stability constant of these complexes has also determined. The studies of these complexes were found to have [M (L)] composition where ... Read more

A robust in vitro Anticancerc, Antioxidant and Antimicrobial Agents Based on New Metal-Azomethine Chelates Incorporating Ag(I), VO(II) and Pd(II) Cations: Probing the Aspects of DNA Interaction

2019-10-19 14:22:17 Keywords DNA interaction, Azomethine Chelates, Antimicrobial activity, Anticancer efficiency, ANTIOXIDANT,
A robust in vitro Anticancerc, Antioxidant and Antimicrobial Agents Based on New Metal-Azomethine Chelates Incorporating Ag(I), VO(II) and Pd(II) Cations: Probing the Aspects of DNA Interaction
A novel azomethine ligand (HNAP) [HNAP = 1-(Pyridin-3-yliminomethyl)-naphthalen-2-ol] and its Ag(I), Pd(II) and VO(II) chelates have been synthesized and structurally inspected using a wide range of spectroscopic and analytical tools, including infra-red (IR), ultraviolet-visible (UV-Vis) and 1H NMR spectroscopy techniques, CHN analysis, molar conductance, magnetic susceptibility, and thermogravimetric analysis. The molar conductance measurements reveal that the chelates are non-electrolytes. The ... Read more

Synthesis and Characterization of New Cr(III), Fe(III) and Cu(II) Complexes Incorporating Multi-Substituted Aryl Imidazole Ligand: Structural, DFT, DNA Binding, and Biological Implications

2019-10-24 21:57:24 Keywords DFT calculation, Antimicrobial activity, DNA interaction, Aryl imidazole metal chelates,
Synthesis and Characterization of New Cr(III), Fe(III) and Cu(II) Complexes Incorporating Multi-Substituted Aryl Imidazole Ligand: Structural, DFT, DNA Binding, and Biological Implications
Designing new metal-based molecular antibiotics is an efficient approach to overcome the growing threat of antimicrobial resistance. In this paper, novel Cr(III), Fe(III) and Cu(II) complexes comprising substituted aryl imidazole ligand (MSEB), namely (2-(1-(2-hydroxyethyl)-4,5-diphenyl-1H-imidazole-2-yl)(4-bromophenol)) have been synthesized and characterized using infra-red (IR), ultraviolet-visible (UV-Vis) and 1H, 13C NMR spectroscopic techniques, together with elemental (CHN) and thermogravimetric analyses, molar conductance, and ... Read more

Synthesis, characterization, DNA cleavage and antimicrobial activity of Schiff base transition metal complexes containing heterocyclic ligand

2018-11-21 09:20:56 Keywords DNA interaction, Schiff base, Transition Metal Complexes, IR, TGA, NMR, Antimicrobial activity, Electronic spectra,
Synthesis, characterization, DNA cleavage and antimicrobial activity of Schiff base transition metal complexes containing heterocyclic ligand
SOME NOVEL SCHIFF BASE METAL COMPLEXES OF CU(II), CO(II), NI(II) AND FE(II) DERIVED FROM 2-AMINO-3-HYDROXYPYRIDINE AND 4-NITROBENZALDEHYDE WERE SYNTHESIZED. THESE COMPOUNDS WERE CHARACTERIZED BY ELEMENTAL ANALYSIS, MOLAR CONDUCTANCE, MAGNETIC SUSCEPTIBILITY, THERMAL MEASUREMENTS, INFRARED AND ULTRAVIOLET–VISIBLE SPECTRA. THE SCHIFF BASE AND METAL COMPLEXES DISPLAYED GOOD ACTIVITY (AGAINST THE BACTERIA, _ESCHERICHIA COLI,__SERRATIA MARCESCENCE_AND_MICROCCUS LUTEUS_, AND THE FUNGI _ASPERGILLUS FLAVUS_, _GETRICHM CANDIDUM _AND ... Read more

Design, Synthesis, anticancer activity and molecular docking studies on a series of VO(II), Cr (III), Mn(II) and Ni(II) Mononuclear Chelates incorporating Quaridentate imine ligand as antitubulin agents

2018-11-21 12:02:43 Keywords Molecular docking analysis, thermal analyses, DNA interaction, Chelates, Antimicrobial activity, IR, NMR, Electronic spectra,
Design, Synthesis, anticancer activity and molecular docking studies on a series of VO(II), Cr (III), Mn(II) and Ni(II) Mononuclear Chelates incorporating Quaridentate imine ligand as antitubulin agents
The present study was conducted to synthesis of some new imine Cr(III), VO(II), Mn(II) and Ni(II) complexes derived from the condensation of 2-amino phenol with 2-hydroxynapthaldehyde were synthesized. The prepared HNPN imine ligand was analyzed by its melting point, IR, 1H NMR and 13C NMR spectroscopies. The investigated HNPN imine complexes were characterized by elemental analysis, FT IR, Uv-vis and ... Read more

Complexation of Schiff bases incorporating of Salicylaldehyde Derivatives and Amino Acids to Copper(II) as an effective strategy for antimicrobial activity improvement, DNA Interaction and catalytic activity

2018-11-22 14:16:13 Keywords Antimicrobial activity, DNA interaction, Amino acids, Catalytic activity, Copper(II), TGA, IR,
Complexation of Schiff bases incorporating of Salicylaldehyde Derivatives and Amino Acids to Copper(II) as an effective strategy for antimicrobial activity improvement, DNA Interaction and catalytic activity
Five Cu(II) complexes are tridentate Schiff bases amino acids ligands derived from condensation 3–methoxysalicylaldehyde (MS) or 4-diethylaminosalicylaldehyde (DS) with α-amino acids (L-phenylalanine(P), L-histidine (H), DL-tryptophane (T)). All ligands are analyzed by 1HNMR and 13CNMR. The investigated complexes have been prepared and characterized by elemental analysis, infrared spectra, ultraviolet-visible and thermal analysis in dynamic air atmosphere (40ml / min) at a ... Read more