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مدرس مساعد - مدرس مساعد بكلية العلوم

كلية العلوم

العنوان: Naser city - sohag- egypt



المنشورات و المؤلفات التي تحتوي علي الكلمة المفتاحية: Synthesis

2020-02-04 19:06:32 الكلمات المفتاحية HDACs Inhibitors;, Ligustrazine, , Anticancer agents, , In silico study, , Synthesis,
Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety
INTRODUCTION: Histone deacetylases (HDACs) represent one of the most validated cancer targets. The inhibition of HDACs has been proven to be a successful strategy for the development of novel anticancer candidates. METHODS: This work describes design and synthesis of a new set of HDAC inhibitors ( 7A-C and 8A, B) utilizing ligustrazine as a novel cap moiety, and achieving the ... إقراء المزيد

2018-12-13 11:56:19 الكلمات المفتاحية Synthesis, maximally entangled, Disentanglement, Josephson charge qubits,
Synthesis of maximally entangled mixed states and disentanglement in coupled Josephson charge qubits
We analyze a controllable generation of maximally entangled mixed states of a circuit containing two-coupled superconducting charge qubits. Each qubit is based on a Cooper pair box connected to a reservoir electrode through a Josephson junction. Illustrative variational calculations were performed to demonstrate the effect on the two-qubits entanglement. At sufficiently deviation between the Josephson energies of the qubits and/or ... إقراء المزيد

2018-11-25 17:26:51 الكلمات المفتاحية Synthesis, DNA interaction, DFT studies, Antimicrobial activity, IR, TGA, Imidazole Ligand,
Synthesis, Characterization and Biological Studies of Some new Cr(III), Fe(III) and Cu(II) Complexes based on Multi-Substituted  Aryl Imidazole ligand
New Cr (III), Fe (III) and Cu (II) complexes with MSBB (2‐(1‐butyl‐4,5 diphenyl‐1H‐imidazol‐2‐yl)(4-bromophenol) were synthesized. The multi-substituted aryl imidazole ligand (MSBB) and its complexes were characterized by using elemental and thermal analysis, molar conductivity, magnetic susceptibility, UV-Vis spectral data, IR, and NMR. The obtained data showed that prepared complexes were 1 :1 (metal : ligand) ratio, octahedral (Oh) for all ... إقراء المزيد

2018-11-01 08:55:29 الكلمات المفتاحية 2-Alkyl-3-alkyloxy-2 H -indaz, Synthesis, Chemsitry,
Synthesis of a Library of 2-Alkyl-3-alkyloxy-2 H -indazole-6-carboxamides
A library of 200 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides was synthesized using parallel solution-phase methods. The indazole cyclization reaction was optimized for library production with the best yields resulting from controlled alcohol/water solvent ratios. The key step, a heterocyclization reaction, proceeds by N,N-bond formation and delivers the 2H-indazole scaffold. Automated preparative HPLC was utilized to provide pure compounds on a 10+ mg scale. إقراء المزيد

2018-10-03 08:46:32 الكلمات المفتاحية Multi-substituted Imidazoles, Synthesis, alkylation, one-pot Multicomponent synthes,
New Method for Synthesis of Multi-substituted Imidazoles
Here, we reported two methods for the synthesis of multi-substituted imidazoles,firstly via four-component cyclocondensation reaction of benzil, aliphatic amines (allylamine or pentylamine), and aromatic aldehyde and ammonium acetate. Using an ionic liquid catalyst namely, diethyl ammonium hydrogen sul-fate, and under solvent-free conditions. Secondly, via the alkylation of synthesized NH imidazoles with alkyl halide (allyl bromide and pentyl bromide) gave8a–cin high ... إقراء المزيد

2018-09-18 21:48:27 الكلمات المفتاحية Synthesis, nitrotetrazole-5-carbaldehyde, Antimicrobial activity, minimum inhibitory concentrati,
Synthesis and Antimicrobial Activity of Substituted Nitrotetrazole-5-Carbaldehyde Hydrazones
A series of substituted -nitrotetrazole-5-carbaldehyde hydrazones were synthesized and tested for antimicrobial activity with respect to _Staphylococcus aureus_, _Streptococcus pneumoniae_, _E. coli_, _P. aeruginosa_, and _Micrococcus_. The minimum inhibitory concentrations were determined. إقراء المزيد

2018-09-18 21:51:09 الكلمات المفتاحية Synthesis, nitrotetrazole-5-carbaldehyde, antifungal activity,
Synthesis and Antifungal Activity of Substituted Nitrotetrazole-5-Carbaldehyde Hydrazones
A series of nitrotetrazole-5-carbaldehyde hydrazones was synthesized and their antifungal activity against _Candida albicans_, _Microsporum canis_, and _Trichophyton rubrum_ was assessed. إقراء المزيد

2018-09-16 21:50:05 الكلمات المفتاحية Antimicrobial activity, Synthesis,
Sonochemical synthesis, DNA binding, antimicrobial evaluation and in vitro anticancer activity of three new nano-sized Cu(II), Co(II) and Ni(II) chelates
Sonochemical synthesis, DNA binding, antimicrobial evaluation and in vitro anticancer activity of three new nano-sized Cu(II), Co(II) and Ni(II) chelates based on tri-dentate NOO imine ligands as precursors for metal oxides إقراء المزيد

2018-09-16 13:40:18 الكلمات المفتاحية TGA, NMR, IR, Calf thymus DNA, Antimicrobial activity, Synthesis, characterization, Nano particle, DNA interaction,
Nano structure Iron (II) and Copper (II) Schiff base complexes of a NNO-tridentate ligand as new antibiotic agents: spectral, thermal behaviors and DNA binding ability
Complexes of Fe (II) and Cu (II) with a tridentate Schiff base, 2-((z)-(pyridine-2-ylimino) methyl) naphthalene1-ol derived from 2-hydroxy-1-napthaldehyde and 2-aminopyridine were synthesized. Both the ligand and its complexes were characterized on the basis of microanalysis, melting point, 1H and 13CNMR, molar conductivity, thermal analysis, IR and UV/Vis spectral studies. From analytical data, the stoichiometry of the complexes was found to ... إقراء المزيد

Sonochemical synthesis, DNA binding, antimicrobial evaluation and in vitro anticancer activity of nano-sized Cu(II), Co(II) and Ni(II) chelates  as precursors for metal oxides
Three new nano sized Cu(II), Co(II) and Ni(II) complexes of imine ligand derived from the condensation of 2-amino-3-hydroxypyridine and 3-methoxysalicylaldehyde have been prepared and investigated using various chemical techniques such as NMR, elemental analysis, molar conductance, IR, electronic spectra, TGA and magnetic momentmeasurements. The obtained chemical analysis data showed that the synthesis of 1:1 (metal:ligand) ratio and octahedral geometry was ... إقراء المزيد

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