ABSTRACT Sirtuin 1 (SIR1) is a NAD+-dependent nuclear deacetylase that is involved in various metabolic pathways affecting energy homeostasis. In this investigation,we aimed to study the association of three SIRT1 gene single nucleotide polymorphisms (SNPs); rs7895833 A/G, rs7069102 C/G and rs2273773 C/T, located on the promotor, intron and exon regions respectively, with essential hypertension and type 2 diabetes mellitus (T2DM). ...
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