ghada_galal

Ghada Galal

Professor - Head of Tropical Medicine and Gastroenterology Department

Faculty of medicine

Address: Sohag, Egypt

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Publications Which contain the keyword: Gene polymorphism


Telomere Dysfunction-Related Serological Markers in Patients with Type 2 Diabetes: Correlation with Methylene Tetrahydofolate Reductase (C677T) Gene Polymorphism and Diabetic Complications
OBJECTIVE: Recent studies have identified a set of serological markers for telomere dysfunction and DNA damage. In the present study, the levels of 2 serological markers of telomere dysfunction namely chitinase and N-acetylglucosaminidase (NAG) were studied in type 2 diabetes mellitus (T2DM) patients. The possibility that genomic damage, accumulation of reactive oxygen species and shorter telomeres may be linked to ... Read more

2018-12-31 14:20:47 Keywords INTERLEUKIN-10, DM, Gene polymorphism,
Association of Interleukin-10 (−592A/C) Gene Polymorphism with its Level in Type 2 Diabetes Mellitus with and without Nephropathy
Abstract Objectives: Several candidate genes are implicated in the pathogenesis of type 2 diabetes mellitus T2DM), one of which is interleukin (IL-10). In this investigation, we aimed to study the association between IL (-592A/C) gene polymorphism with its level in T2DM with and without nephropathy. Methods: IL-10 (-592A/C) gene polymorphism was genotyped using restriction fragment length polymorphism (RFLP-PCR) technique and ... Read more

2018-10-02 13:10:59 Keywords PTX3, Gene polymorphism, Pulmonary Tuberculosis,
Pentraxin 3 Genetic Variants and The Risk of Active Pulmonary Tuberculosis
Tuberculosis is a major health problem worldwide. Genetic factors are considered important determinants of the host susceptibility to Mycobacterium tuberculosis. The aim of the current study was to evaluate the association between pentraxin 3 genetic variants and the susceptibility and severity of active pulmonary tuberculosis. The study included 100 patients with newly diagnosed pulmonary TB and 50 healthy controls. PTX3 ... Read more

Interleukin-10 and Interferon Gamma Gene Polymorphisms and Hepatitis C Virus–Related Liver Cirrhosis Risk
The aim of the study was to evaluate the association between the gene polymorphisms in interleukin-10 (IL-10) and interferon gamma (IFN-g) genes with susceptibility and severity of hepatitis C virus (HCV) infection among Egyptian patients. Interleukin-10 -592 A/C, -1082 G/A and IFN-g +874 T/A genotypes were determined in 100 chronic HCV patients and 50 healthy controls using restriction fragment length ... Read more

2018-09-18 19:28:51 Keywords Gene polymorphism, hepatitis C,
Interleukin-10 and Interferon Gamma Gene Polymorphisms and Hepatitis C Virus–Related Liver Cirrhosis Risk
The aim of the study was to evaluate the association between the gene polymorphisms in interleukin-10 (IL-10) and interferon gamma (IFN-g) genes with susceptibility and severity of hepatitis C virus (HCV) infection among Egyptian patients. Interleukin-10 -592 A/C, -1082 G/A and IFN-g +874 T/A genotypes were determined in 100 chronic HCV patients and 50 healthy controls using restriction fragment length ... Read more

Vitamin D level and Fok-I vitamin D receptor gene polymorphism in Egyptian patients with type-1 diabetes
Many cellular, preclinical and observational studies support a role of vitamin D in pathogenesis of type-1 diabetes mellitus (DM). The vitamin D receptor (VDR) locus has been studied in different populations for association with susceptibility to immune-mediated diseases, but with inconsistent findings in type-1 DM. This study aimed to investigate vitamin D status in patients with type-1 DM. We examined ... Read more

Association of sirtuin 1 gene single nucleotide polymorphisms with type 2 diabetes mellitus in essential hypertension patients
ABSTRACT Sirtuin 1 (SIR1) is a NAD+-dependent nuclear deacetylase that is involved in various metabolic pathways affecting energy homeostasis. In this investigation,we aimed to study the association of three SIRT1 gene single nucleotide polymorphisms (SNPs); rs7895833 A/G, rs7069102 C/G and rs2273773 C/T, located on the promotor, intron and exon regions respectively, with essential hypertension and type 2 diabetes mellitus (T2DM). ... Read more

2018-09-15 15:14:13 Keywords INTERFERON-γ, hepatitis C virus, Gene polymorphism,
Interlukin-10 and Interferon Gamma Gene Polymorphisms and Hepatitis C Virus-Related Liver Cirrhosis Risk
ABSTRACT: _OBJECTIVES:_ We aimed to find the relation between the gene polymorphisms in interleukin-10 and interferon- γ genes with susceptibility and severity of HCV infection among Egyptian patients. _PATIENTS AND METHODS_: Interleukin-10 -592 A/C, -1082 G/A and IFN-γ +874 T/A genotypes were determined in 50 chronic HCV patients, 50 HCV cirrhotic patients and 50 health controls. _RESULTS_: IL10-592A/C polymorphism genotyping ... Read more