mamdouh.fawzi

Mamdouh Fawzy Ahmed Mohamed

Lecturer - Lecturer of Pharmaceutical Chemistry, Head of Pharmaceutical Chemistry Department Lab and Co-ordinate of Clinical Pharmacy Program

Faculty of Pharmacy

Address: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt

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Publications Which contain the keyword: Docking

Design, synthesis, mechanistic and histopathological studies of small- molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol- 1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production

2018-10-06 15:25:55 Keywords Docking, Anti-cancer,
Design, synthesis, mechanistic and histopathological studies of small- molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol- 1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production
A series of novel compounds carrying pyrazino[1,2-a]indol-1(2H)-one scaffold (5a-g) and their reac- tion intermediates, indole-2-carboxamides, (3a-g) were synthesized and evaluated for their ability to inhibit reactive oxygen species (ROS) generation, antioxidant activity and anticancer activity against a panel of cancer cell lines using MTT assay. The results showed that these compounds can inhibit ROS generation during the metabolic phase of ... Read more

Synthesis, theoretical investigations, biocidal screening, DNA binding, in vitro cytotoxicity and molecular docking of novel Cu (II), Pd (II) and Ag (I) complexes

2018-09-30 06:29:59 Keywords imines, NLO properties, Docking, Cytotoxicity, CT‐DNA, Antimicrobial activity, chlorobenzilidine, IR, TGA, NMR,
Synthesis, theoretical investigations, biocidal screening, DNA binding, in vitro cytotoxicity and molecular docking of novel Cu (II), Pd (II) and Ag (I) complexes
Three new Cu(II), Pd(II) and Ag(I) complexes with bi-dentate Schiff base ligand "HL" namely 2-[(4-Chloro-benzylidene)-amino]-phenol were synthesized. The stoichiometric ratios and physicochemical properties of these complexes were determined using elemental analyses (C, H, and N), magnetic measurements, IR, UV-Vis spectra, molar conductivity and thermal analyses. The results revealed that the metal ions coordinated with ligand HL through azomethine nitrogen and ... Read more

DNA Interaction, Antimicrobial, Anticancer Activities and Molecular Docking Study of Some New VO(II), Cr (III), Mn(II) and Ni(II) Mononuclear Chelates encompassing Quaridentate imine ligand

2018-09-12 21:18:45 Keywords DNA interaction, Molecular Doc, Molecular Docking Study, DNA interaction, Antimicrobial, Docking, Anticancer,
DNA Interaction, Antimicrobial, Anticancer Activities and Molecular Docking Study of Some New VO(II), Cr (III), Mn(II) and Ni(II) Mononuclear Chelates encompassing Quaridentate imine ligand
The present study was conducted to synthesis of some new imine Cr(III), VO(II), Mn(II) and Ni(II) complexes derived from the condensation of 2-amino phenol with 2-hydroxynapthaldehyde were synthesized. The prepared HNPN imine ligand was analyzed by its melting point, IR, (1)H NMR and (13)C NMR spectroscopies. The investigated HNPN imine complexes were characterized by elemental analysis, FT IR, UV-vis and ... Read more

DNA interaction, antimicrobial, anticancer activities and molecular docking study of some new VO(II), Cr(III), Mn(II) and Ni(II) mononuclear chelates encompassing quaridentate imine ligand

2018-09-06 07:47:58 Keywords NMR, VO(II), imines, Chelates, thermal analyses, Antimicrobial activity, DNA interaction, Anticancer, IR, TGA, Docking, Cr(III),
DNA interaction, antimicrobial, anticancer activities and molecular docking study of some new VO(II), Cr(III), Mn(II) and Ni(II) mononuclear chelates encompassing quaridentate imine ligand
The present study was conducted to synthesis of some new imine Cr(III), VO(II), Mn(II) and Ni(II) complexes derived from the condensation of 2-amino phenol with 2-hydroxynapthaldehyde were synthesized. The prepared HNPN imine ligand was analyzed by its melting point, IR, 1H NMR and 13C NMR spectroscopies. The investigated HNPN imine complexes were characterized by elemental analysis, FT IR, UV–vis and ... Read more

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