Ghada Galal

Professor - Head of Tropical Medicine and Gastroenterology Department

Faculty of medicine

Address: Sohag, Egypt



Publications Which contain the keyword: Endometriosis

2020-01-16 03:52:03 Keywords PAI-1, Endometriosis, IHC,
Plasminogen activator inhibitor-1 (PAI-1) expression in endometriosis
ABSTRACT PURPOSE Deep infiltrating endometriosis (DIE) is defined as an endometriotic lesion penetrating to a depth of >5 mm and is associated with pelvic pain, but the underlying mechanisms are unclear. Our objective is to investigate whether plasminogen activator inhibitor-1 expression (PAI-1) in endometriotic tissues is increased in women with DIE. METHODS In this blinded _in vitro_ study, immunohistochemistry and ... Read more

2020-03-03 08:23:59 Keywords Immunohistochemistry, metastin, Endometriosis, KISS1, Kisspeptin,
Immunoreactivity of Kisspeptin and Kisspeptin Receptor in Eutopic and Ectopic Endometrial Tissue of Women With and Without Endometriosis
Endometriosis is characterized by the presence of ectopic endometrial tissues. Mechanisms of tissue dissemination in endometriosis may be similar to those involved in tumor metastasis. We hypothesize that dysregulation of kisspeptin (KISS1), a metastasis suppressor in endometrial carcinoma, may contribute to the pathogenesis of endometriosis. In this study, we characterized the immunoreactivity of kisspeptin and its receptor, KISS1R, in eutopic ... Read more

2018-10-29 16:37:22 Keywords cytokines, Endometriosis, cyclooxygenase-2,
Evaluation of the Possible Role of Cyclooxygenase-2 in Endometriosis
Abstract: Endometriosis is a common, complex and chronic disease related to ectopic implantation and growth of endometrial tissue. Endometriosis is characterized by the presence and/or the growth of endometrial tissue (both glands and stroma) outside the uterine cavity that causes inflammation inside or outside the pelvis. This study aimed to investigate the possible role of COX-2 in endometriosis and its ... Read more

2018-09-13 04:12:49 Keywords Immunohistochemistry, Kisspeptin, Endometriosis,
Differential expression of Kisspeptin in patients with and without endometriosis
OBJECTIVE Kisspeptin is a neuropeptide that belongs to the Rfamide family. It is known for its crucial role in regulating the onset of puberty. In addition it also regulates sex hormone mediated secretion of gonadotrophins. Recently, expression of Kisspeptin in endometrium was reported. Kisspeptin has also been shown to have antimetastatic properties in different types of cancer. Endometriosis shares many ... Read more

2018-09-13 04:15:54 Keywords Immunohistochemistry, Kisspeptin, Endometriosis,
Differential expression of Kisspeptin and its receptor in eutopic and ectopic endometrium of women with and without endometriosis
OBJECTIVE: The neuropeptide Kisspeptin regulates gonadotrophin-releasing hormone release from the hypothalamus and is expressed peripherally in the endometrium. It also has anti-metastatic effects in many types of cancer. Like cancer, endometriosis exhibits migration and invasiveness. Our objective was to evaluate the expression of Kisspeptin and its receptor in different endometriotic lesions. DESIGN: This is a case control study. MATERIALS AND ... Read more

2018-09-08 22:21:15 Keywords Endometriosis, Endometrial Tissues, HOXB4,
HOXB4 Immunoreactivity in Endometrial Tissues From Women With or Without Endometriosis
Endometriosis is a common disease characterized by the presence of ectopic endometrial tissue. Although the pathogenesis of endometriosis remains unclear, several factors have been implicated, including the dysregulation of homeobox (HOX) genes. Our objective was to investigate the localization and immunoreactivity of HOXB4 in endometrial tissues from women with or without endometriosis. We studied samples of eutopic endometrium (EE), endometriomas ... Read more