essameldin_nada

Essameldin Abdelaziz Mohamed Ahmed Nada

Professor - Prof. of Dermatology,Venereology and Andrology

Faculty of medicine

Address: 8 Abou Bakr ElSedik Dokki Giza

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Publications Which contain the keyword: Epigenetics


جيناتك ليست قدرك. Genes and the Environment: The Science of Epigenetics
At one time scientists believed that our DNA carry the key to preventing and reversing disease, but now we know that the environment and not our genes is the primary triggering of health and longevity. The science of epigenetics is explaning what we’ve long think about our biological destiny upside/ down. Although it remains that our DNA and our genetic ... Read more

2018-09-03 22:07:17 Keywords Epigenetics, Histone Modification, MSCs,
Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes
Somatic mutations in the isocitrate dehydrogenase (IDH)1/2 genes endow encoding proteins with neomorphic activity to produce the potential oncometabolite, 2-hydroxyglutarate (2-HG), which induces the hypermethylation of histones and DNA. The incidence of IDH1/2 mutations in cartilaginous tumors was previously shown to be the highest among various types of tumors, except for those in the central nervous system. Mutations have been ... Read more