ahmedabudief

Dr. Ahmed Mohamed Abu-Dief

Professor - Professor of Physical and Inorganic Chemistry

Faculty of science

Address: Behind hospital of Sohag University - Ali Ebn Abi Taleb Street

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Publications Which contain the keyword: Pyrimidine

Rapidly and Highly Yielded Synthesis of Pyrimidine, Dihydropyrimidinone, and Triazino[2,1‐b]quinazolin‐6‐ones Derivatives

2018-09-20 10:59:25 Keywords Pyrimidine, Dihydropyrimidinon,
Rapidly and Highly Yielded Synthesis of Pyrimidine, Dihydropyrimidinone, and Triazino[2,1‐b]quinazolin‐6‐ones Derivatives
The reaction of 4‐oxo‐3,4‐dihydroquinazolinyl‐2‐guanidine 1 with several active methylene compounds has revealed formation of the corresponding hydropyrimidine and dihydropyrimidnone (DHPMs) derivatives via cycloaddition reaction mechanism. Satisfactory results were obtained with good yields, short time, and simplicity in the experimental procedure. Reaction with ketones in DMF proceeded via (5+1) heterocyclization and resulted in the formation of 2‐amino‐4‐(het)aryl‐4,6‐dihydro‐1(3)(11)H‐[1,3,5] triazino[2,1‐b]quinazolin‐6‐ones 8‐13, respectively. All ... Read more

Synthesis of Some New F used P yridines and Prediction their Biological Activity via PASS INET

2018-09-18 21:57:39 Keywords PASS INET, fused pyridine, pyrrazole, Pyrimidine, pyrrole, pyridine, phase transfer catalysis,
Synthesis of Some New F used P yridines and Prediction their Biological Activity via PASS INET
A new series of fused heterocyclic compounds containing pyridine moieties were prepared via the reaction of 2-amino-6-(methylthio)-4-phenylpyridine-3,5-dicarbonitrile with some halo reagents, active methylenes, acetic anhydride, phenylisothiocyanate, hydrazine hydrate or thioacetamide. Accompanied with Predictions of the activity spectra of some selected compounds using PASS INET.at Pa > 70%, showing high probability of Atherosclerosis treatment, Antineoplastic, DNA intercalator, Protein kinase inhibitor and ... Read more

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