Detailed Studies of the Alkylation Sides of Pyridin-2-yl and 4,6-Dimethylpyrimidin-2-yl-cyanamides
Pyridin-2-yl- and 4,6-dimethylpyrimidin-2-yl-cyanamides entered into an alkylation reaction in the form of sodium salts. Pyridin-2-yl cyanamide 2 was alkylated at endo-nitrogen atom of pyridine ring, while 4,6-dimethylpyrimidin-2-yl cyanamide 1 was effectively alkylated at exo-nitrogen atom of amino cyanamide group. The alkylation of cyanamides 1 and 2 with phenacylbromide gave the corresponding acetophenone derivatives. As a result of their intramolecular cyclization ... Read more