Dr.ramykamal

Ramy Kamal Amin Sayed

Lecturer - Lecturer of Veterinary Anatomy and Embryology

Faculty of Veterinary Medicine

Address: Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Sohag University

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Publications Which contain the keyword: melatonin


2018-10-14 18:19:52 Keywords Heart, melatonin, NF-κB, NLRP3 deficiency, NLRP3 inflammasome, Sepsis,
Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis
The NLRP3 inflammasome is involved in the innate immune response during inflammation. Moreover, melatonin blunts the NF-κB/ NLRP3 connection during sepsis. Thus, we compared the roles of the NLRP3 inflammasome and/or melatonin treatment in the septic response of wild-type and NLRP3−/− mice. Mouse myocardial tissue was used for this purpose. The nuclear turnover of NF-κB was enhanced during sepsis, with ... Read more

2018-10-14 18:38:28 Keywords melatonin, radiotherapy, small intestine toxicity,
Melatonin protects rats from radiotherapy-induced small intestine toxicity
Radiotherapy-induced gut toxicity is among the most prevalent dose-limiting toxicities following radiotherapy. Prevention of radiation enteropathy requires protection of the small intestine. However, despite the prevalence and burden of this pathology, there are currently no effective treatments for radiotherapy-induced gut toxicity, and this pathology remains unclear. The present study aimed to investigate the changes induced in the rat small intestine ... Read more

Melatonin, clock genes and mitochondria in sepsis
After the characterization of the central pacemaker in the suprachiasmatic nucleus, the expression of clock genes was identified in several peripheral tissues including the immune system. The hierarchical control from the central clock to peripheral clocks extends to other functions including endocrine, metabolic, immune, and mitochondrial responses. Increasing evidence links the disruption of the clock genes expression with multiple diseases ... Read more

In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy
Although mitochondria dysfunction is related to multiple diseases, no in vivo studies are available on mitochondrial respiration in animal parkinsonian models. Our aim is to analyze in vivo mitochondrial respiration, which reflects changes in mitochondrial bioenergetics more precisely than in vitro mitochondrial preparations. These experiments can be carried out in zebrafish embryos, which were treated with 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) from ... Read more

2018-10-14 19:02:29 Keywords Aging, Apoptosis, autophagosome, melatonin, gastrocnemius, Sarcopenia,
The protective effect of melatonin against age-associated sarcopenia-dependent tubular aggregates formation, lactate depletion and mitochondrial changes
To gain insight into the mechanism of sarcopenia and the protective effect of melatonin, the gastrocnemius muscles of young (3-4 months), early-aged (12 months), and old-aged (24 months) wild type C57BL/6J female mice, were examined by magnetic resonance and microscopy. Locomotor activity, lactate production and nuclear apoptosis were also assessed. The results support the early onset of sarcopenia at 12 ... Read more

2018-10-13 20:24:10 Keywords CHANGES, melatonin, age related,
AGE RELATED CHANGES AND MELATONIN
BACKGROUND:. Melatonin ( N-acetyl-5-methoxy-tryptamine )is a neurohormone that is secreted by a small gland in the center of the brain called the pineal gland. Aging is accompanied by changes in the morphology and physiology of organs and tissues. This process might be due to the accumulation of oxidative damage induced by reactive oxygen (ROS) and reactive nitrogen species (RNS). OBJECTIVES: ... Read more

2018-10-14 17:37:04 Keywords Aging, Sarcopenia, Inflammaging, Innate immunity, melatonin,
Aging and Sarcopenia. Role of the innate immunity and melatonin therapy
La inflamación asociada al envejecimiento es un tipo de inflamación crónica, sistémica y asintomática que aparece como resultado de un aumento de la respuesta inmune innata con la edad. Los estímulos que dan lugar a este tipo de inflamación convergen en la activación de las vías moleculares de la inmunidad innata NF-kB y el inflamasoma NLRP3. La inflamación asociada al ... Read more

2018-10-14 17:54:44 Keywords Mitochondrial function, cancer, melatonin,
Oncostatic effect of melatonin in head and neck cancer: role of mitochondrial function
Cancer cells have some special features that give them the ability to change and to resist different types of treatments. These changes are produced by modifications in the mitochondrial bioenergetics, that is, a switch in the metabolism. These advantages consist in the so-called Warburg effect. Cancer cells depend on glycolysis instead of oxidative phosphorylation to get the energy necessary to ... Read more

The benefit of a supplement with the antioxidant melatonin on redox status and muscle damage in resistance-trained athletes
Previous data showed that the administration of high doses of melatonin improved the circadian system in athletes. Here, we investigated in the same experimental paradigm whether the antioxidant properties of melatonin has also beneficial effects against exercise-induced oxidative stress and muscle damage in athletes. Twenty-four athletes were treated with 100 mg.day-1 of melatonin or placebo 30 min before bedtime during ... Read more

2018-09-25 16:21:35 Keywords melatonin, roetgen, enteritis,
Melatonin and roentgen irradiation-induced acute radiation enteritis in Albino rats: An animal model
_Background_: Roentgen irradiation can affect normal cells, especially the rapidly growing ones such as the mucosal epithelial cells of the small intestine. The small intestine is the most radiosensitive gastrointestinal organ and patients receiving radiotherapy directed to the abdomen or pelvis may develop radiation enteritis. Although roentgen rays are widely used for both imaging and therapeutic purposes, our knowledge about ... Read more