To evaluate the efficacy the possible mechanism of action of strontium ranelate (SR) in the treatment of knee OA induced by mono-sodium-iodoacetate (MIA) as a new indication of this drug, also, to detect whether cartilage oligomeric matrix protein (COMP) is a reliable biomarker that can facilitate the diagnosis of osteoarthritis (OA). METHODS: twenty-four adult male _Swiss_ albino rats weighing 150–200 ... إقراء المزيد