A series of novel histone deacetylase inhibitors (HDACIs)/chalcone hybrids bearing hydroxamic acid or 2- aminobenzamide group as zinc binding groups (ZBG) were synthesized. The structural formula of the prepared compounds was fully characterized by IR, NMR and elemental microanalyses. Most of the tested compounds showed moderate to strong Histone deacetylase (HDAC) inhibitory activity. In particular, compounds 3b, 3c, 3d and ... Read more