Design, synthesis, mechanistic and histopathological studies of small- molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol- 1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production
A series of novel compounds carrying pyrazino[1,2-a]indol-1(2H)-one scaffold (5a-g) and their reac- tion intermediates, indole-2-carboxamides, (3a-g) were synthesized and evaluated for their ability to inhibit reactive oxygen species (ROS) generation, antioxidant activity and anticancer activity against a panel of cancer cell lines using MTT assay. The results showed that these compounds can inhibit ROS generation during the metabolic phase of ... Read more