Association of osteopontin promoter polymorphism and aggresivness        in breast cancer
Abstract Osteopontin (OPN) is an extracellularmatrix protein that is overexpressed in various cancers and promotes oncogenic features including cell proliferation, survival,migration, and angiogenesis, among others. OPN can participatein the regulation of the tumormicroenvironment, affecting both cancer and neighboring cells. Here,we review The role of single-nucleotide polymorphism (SNP)-443 of the OPN gene in cancer aggressiveness. إقراء المزيد