ghada_galal

Ghada Galal

Professor - Head of Tropical Medicine and Gastroenterology Department

Faculty of medicine

Address: Sohag, Egypt

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Publications Which contain the keyword: Colorectal cancer


2019-02-08 01:08:26 Keywords Colorectal cancer, Ceramide, P53, tamoxifen, P-glycoprotein,
Tamoxifen magnifies therapeutic impact of ceramide in human colorectal cancer cells independent of p53.
Poor prognosis in patients with later stage colorectal cancer (CRC) necessitates the search for new treatment strategies. Ceramide, because of its role in orchestrating death cascades in cancer cells, is a versatile alternative. Ceramide can be generated by exposure to chemotherapy or ionizing radiation, or it can be administered in the form of short-chain analogs (C6-ceramide). Because intracellular P-glycoprotein (P-gp) ... Read more

2018-10-23 20:22:05 Keywords Colorectal cancer, adenoma, Carcinoma, , Bcl-2, Bax , P53, Ki-67, , ApopTag, , β-Catenin,
Markers defining colorectal adenoma-carcinoma progression: a computerized image analysis protocol
ABSTRACT: The vast majority of colorectal carcinoma are widely believed to arise from polypoid adenomas. The apoptotic related genes that have been most consistently characterized in colonic cancer are bcl-2, bax, and p53. Studying the expression of these genes in adenoma carcinoma sequence will be of great value in producing the clinical behavior of benign tumors. Loss of contact inhibition ... Read more

Association of Paraoxonase-1(Q192R and L55M) Gene Polymorphisms and Activity with Colorectal Cancer and Effect of Surgical Intervention
Background: Colorectal cancer (CRC) is a leading cause of cancer-related death. Oxidative DNA damage may contribute to cancer risk and the antioxidant paraoxonase is one endogenous free radical scavenger in the human body which could therefore exert an influeence. Purpose: Aim of this study was to determine the role of serum arylesterase (ARE) and paraoxonase 1(PON1) activities in CRC patients ... Read more