This paper presents an analytical approach associated with Laplace transformation, experimental temperature data, and a sequential concept over time to obtain the thermal damage and the temperature in a living tissue due to laser irradiation. The analytical solutions in the Laplace domain are appreciably obtainable. The thermal damage to the tissue is completely assessed by the denatured protein range using the formulation of Arrhenius. Numerical outcomes for temperatures and the thermal damages are graphically introduced. Besides, the comparison between the numerical computations and the existing experimental study shows that a current mathematical model is an effective tool for evaluating the biological heat transfer in biological tissues.