The present paper covers the study of limestone consolidants based on acrylic polymer (Paraloid B-72), Ca(OH)2 nanoparticles (Nanolime) and the acrylic polymer mixed with Ca(OH)2 nanoparticles. The experimental study was conducted on limestone samples from El-Ashmunein archaeological area, Minia, Egypt. Some tests were done for studying the behavior of the consolidants used. The main goal of these tests was to estimate the consolidants efficiency and investigate the changes of physio-mechanical properties of the studied samples before and after consolidation, as well as after artificial aging. Therefore, laboratories measurements such as weight change, chromatic variations, physio-mechanical and SEM were performed. It was observed that there are noticeable differences among stone physio-mechanical properties of samples after treatment and after artificial aging according to the types of consolidant. It was found out, the best efficiency was the mixture of Paraloid B-72 and Ca(OH)2 nanoparticles, followed by Ca(OH)2 nanoparticles (Nanolime) dispersion in ethanol 2.5%, then Paraloid B-72 2%. The obtained results showed a significant improvement in physio-mechanical properties of the samples treated by the mixture of Paraloid B-72 and Ca(OH)2 nanoparticles, e.g., increase in bulk density from 2.02 to 3.55 g/cm3 and decrease in porosity from 25.09% to 13.74%, as well as a noticeable increase in compressive strength.